寄生虫热休克蛋白60在免疫反应中的作用及其治疗应用

IF 1.4 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular and biochemical parasitology Pub Date : 2023-02-01 DOI:10.1016/j.molbiopara.2023.111544

Xuedong He , Yue Sun , Fang Yang , Guanghui Zheng , Rui Li , Mengqi Liu , Wanjing Li , Dong-Hui Zhou , Yadong Zheng

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引用次数: 1

摘要

热休克蛋白60（HSP60）是热休克蛋白家族中的一个独特成员，与寄生虫感染有关。为了应对寄生虫生活的恶劣环境，HSP60是必不可少的，并参与了各种生物过程。HSP60在寄生虫中的相似性相对较低，但其ATPase/Mg2+活性位点高度保守。HSP60与免疫细胞中信号通路调节因子的相互作用表明其在免疫反应中发挥着至关重要的作用，使其成为潜在的治疗靶点。本文从分子特征、免疫调节反应和基于HSP60的治疗方法等方面综述了目前对寄生蠕虫HSP60的认识。

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Heat shock protein 60 in parasitic helminths: A role in immune responses and therapeutic applications

Heat shock protein 60 (HSP60) is an unique member of the heat shock protein family, being involved in parasite infections. To cope with harsh environments where parasites live, HSP60s are indispensable and involved in a variety of biological processes. HSP60s have relative low similarity among parasites, but their ATPase /Mg²⁺ active sites are highly conserved. The interactions of HSP60s with signaling pathway regulators in immune cells suggest a crucial role in immune responses, rendering them a potential therapeutic target. This paper reviews the current understandings of HSP60s in parasitic helminths in aspects of molecular characteristics, immunoregulatory responses and HSP60-based therapeutics.

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来源期刊

Molecular and biochemical parasitology 医学-寄生虫学

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

63 days

期刊介绍： The journal provides a medium for rapid publication of investigations of the molecular biology and biochemistry of parasitic protozoa and helminths and their interactions with both the definitive and intermediate host. The main subject areas covered are: • the structure, biosynthesis, degradation, properties and function of DNA, RNA, proteins, lipids, carbohydrates and small molecular-weight substances • intermediary metabolism and bioenergetics • drug target characterization and the mode of action of antiparasitic drugs • molecular and biochemical aspects of membrane structure and function • host-parasite relationships that focus on the parasite, particularly as related to specific parasite molecules. • analysis of genes and genome structure, function and expression • analysis of variation in parasite populations relevant to genetic exchange, pathogenesis, drug and vaccine target characterization, and drug resistance. • parasite protein trafficking, organelle biogenesis, and cellular structure especially with reference to the roles of specific molecules • parasite programmed cell death, development, and cell division at the molecular level.