{"title":"间变性弥漫性大b细胞淋巴瘤:具有欺骗性的形态学。","authors":"Priyadharshini Sivasubramaniam, Aishwarya Ravindran","doi":"10.5045/br.2023.2022247","DOIUrl":null,"url":null,"abstract":"An elderly male without significant past medical history presented with cervical lymphadenopathy. Labs showed anemia (Hb 7.6 g/dL) and elevated WBC count (16×10 9 /L) with neutrophilia. Limited core biopsy revealed partial nodal involvement by an overtly malignant proliferation with marked anaplasia including multinucleated forms (A, B) and appeared to display a somewhat cohesive pattern of growth suggestive of an epithelioid neoplasm. Flow cytometry showed no immunophenotypic evidence of lymphoma. The primary differential diagnosis based on these findings included a poorly-differentiated carcinoma versus melanoma, however, immunostains for keratin, Melan A and SOX10 were negative. CD45 was only performed subsequently due to receipt of the case for hematopathologist evaluation given the lymphadenopathy. Surprisingly, the anaplastic tumor cells (A ×40; B ×200; C ×400) were diffusely CD45-positive; subsequent immunostains revealed positivity","PeriodicalId":46224,"journal":{"name":"Blood Research","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b0/7b/br-58-1-1.PMC10063593.pdf","citationCount":"0","resultStr":"{\"title\":\"Anaplastic diffuse large B-cell lymphoma: a deceptive morphology.\",\"authors\":\"Priyadharshini Sivasubramaniam, Aishwarya Ravindran\",\"doi\":\"10.5045/br.2023.2022247\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"An elderly male without significant past medical history presented with cervical lymphadenopathy. Labs showed anemia (Hb 7.6 g/dL) and elevated WBC count (16×10 9 /L) with neutrophilia. Limited core biopsy revealed partial nodal involvement by an overtly malignant proliferation with marked anaplasia including multinucleated forms (A, B) and appeared to display a somewhat cohesive pattern of growth suggestive of an epithelioid neoplasm. Flow cytometry showed no immunophenotypic evidence of lymphoma. The primary differential diagnosis based on these findings included a poorly-differentiated carcinoma versus melanoma, however, immunostains for keratin, Melan A and SOX10 were negative. CD45 was only performed subsequently due to receipt of the case for hematopathologist evaluation given the lymphadenopathy. Surprisingly, the anaplastic tumor cells (A ×40; B ×200; C ×400) were diffusely CD45-positive; subsequent immunostains revealed positivity\",\"PeriodicalId\":46224,\"journal\":{\"name\":\"Blood Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2023-03-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b0/7b/br-58-1-1.PMC10063593.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Blood Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5045/br.2023.2022247\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Blood Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5045/br.2023.2022247","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"HEMATOLOGY","Score":null,"Total":0}
Anaplastic diffuse large B-cell lymphoma: a deceptive morphology.
An elderly male without significant past medical history presented with cervical lymphadenopathy. Labs showed anemia (Hb 7.6 g/dL) and elevated WBC count (16×10 9 /L) with neutrophilia. Limited core biopsy revealed partial nodal involvement by an overtly malignant proliferation with marked anaplasia including multinucleated forms (A, B) and appeared to display a somewhat cohesive pattern of growth suggestive of an epithelioid neoplasm. Flow cytometry showed no immunophenotypic evidence of lymphoma. The primary differential diagnosis based on these findings included a poorly-differentiated carcinoma versus melanoma, however, immunostains for keratin, Melan A and SOX10 were negative. CD45 was only performed subsequently due to receipt of the case for hematopathologist evaluation given the lymphadenopathy. Surprisingly, the anaplastic tumor cells (A ×40; B ×200; C ×400) were diffusely CD45-positive; subsequent immunostains revealed positivity