更年期:乙状结肠新阴道和残余结肠同时发生溃疡性结肠炎的诱因?

IF 1.6 Q3 OBSTETRICS & GYNECOLOGY
Minerva obstetrics and gynecology Pub Date : 2024-06-01 Epub Date: 2023-02-16 DOI:10.23736/S2724-606X.23.05224-7
Massimo Candiani, Francesco Fedele, Simona DI Fatta, Gianluca Taccagni, Carolina Dolci, Alessandro F Ruffolo
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引用次数: 0

摘要

使用乙状结肠进行阴道成形术是创建新阴道的常用技术。然而,新阴道的不良肠道事件风险是常见的缺点。我们报告了这样一例病例:一名女性在 24 岁时因患 Mayer-Rokitansky-Küster-Hauser (MRKH) 综合征而接受了肠阴道成形术,随着更年期的到来,她出现了带血的阴道分泌物。几乎与此同时,患者主诉左下腹痛和长期腹泻。全身检查、子宫颈抹片检查、微生物检查和人乳头瘤病毒检测均为阴性。新阴道活检提示为中度活动性炎症性肠病(IBD),结肠活检提示为溃疡性结肠炎(UC)。随着绝经期的到来,乙状结肠新阴道和剩余结肠几乎同时出现 UC,这对这些疾病的病因和发病机制提出了重要问题。我们的病例表明,由于与更年期有关的结肠表面通透性的变化,更年期可能是诱发 UC 的一个因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Menopause: a trigger for simultaneous development of ulcerative colitis in sigmoid neovagina and residual colorectum?

Vaginoplasty using sigmoid colon is a common technique used for the creation of a neovagina. However, the risk of adverse neovaginal bowel events is a common mentioned disadvantage. We report the case of a woman submitted to intestinal vaginoplasty for Mayer-Rokitansky-Küster-Hauser (MRKH) Syndrome at the age of 24 years who, with the onset of menopause, developed blood-stained vaginal discharge. Almost simultaneously, the patients complained chronic abdominal pain in lower left quadrant and prolonged diarrhea. General exams, Pap smear test, microbiological tests and viral test for HPV were negative. Neovaginal biopsies were suggestive for inflammatory bowel disease (IBD) of moderate activity and colonic biopsies were suggestive for ulcerative colitis (UC). The development of UC in the sigmoid neovagina and, almost simultaneously, in the remaining colon with onset of menopause raises important questions about etiology and pathogenesis of these diseases. Our case suggests that menopause may consider a trigger for the development of UC, due to the changes in the colon surface permeability related to menopause.

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来源期刊
Minerva obstetrics and gynecology
Minerva obstetrics and gynecology OBSTETRICS & GYNECOLOGY-
CiteScore
2.90
自引率
11.10%
发文量
191
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