艾滋病毒感染者的虚弱和衰老问题在全国范围内引起关注已有 13 年之久。

IF 3.3 Q2 GERIATRICS & GERONTOLOGY
U A Eke, K Mohanty, A L Gruber-Baldini, A S Ryan
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引用次数: 0

摘要

在美国,50 岁及以上的艾滋病毒感染者(PLWH)占 50%以上。尽管抗逆转录病毒疗法在延长他们的寿命方面取得了进展,但艾滋病毒感染者仍受到与艾滋病无关的疾病的困扰,这增加了他们发病和死亡的风险。衰弱是指身体和功能储备下降,是衰老的表现之一,发病率为 5%-30%,在艾滋病病毒感染者(PAWH)中最多可提前 20 年出现。大多数艾滋病毒携带者和艾滋病患者的医疗服务提供者对老年学、虚弱和衰老的概念知之甚少。因此,临床医生在如何应对艾滋病感染者衰弱和老龄化方面的知识存在空白。本综述将重点关注可减轻小儿麻痹症患者虚弱和衰老的临床干预措施,并强调实现这些干预措施的研究领域。除了确定运动和营养的作用外,还需要对将这些资源应用于常规护理的实用方法进行更多研究。应继续加强行之有效的抗逆转录病毒联合疗法策略,以及对合并感染的治疗和适龄健康和癌症筛查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Frailty and Aging in HIV- Status Post 13 Years of National Awareness.

The People aged 50 years and above comprise over 50% of people living with HIV (PLWH) in the US. Despite the advances made with anti-retroviral therapy in increasing their life span, PLWH are plagued with non-AIDS associated conditions which increase their risk for morbidity and mortality. Frailty, a decline in physical and functional reserve, is one of the manifestations of aging, has a prevalence of 5-30%, and occurs up to 2 decades earlier in people aging with HIV (PAWH). The majority of providers for PAWH have minimal experience with the concept of gerontology, frailty, and aging. Hence, there is a gap in clinicians' knowledge on how to address frailty and aging in PAWH. This review will focus on the clinical interventions that mitigate frailty and aging in PAWH as well as highlight areas of investigation towards achieving these mediations. Beyond the identification of the roles of exercise and nutrition, more studies are needed on the pragmatic approach to apply these resources to routine care. There should be continued reinforcement of the proven strategy of combination antiretroviral therapy as well as treatment of co-infections and age-appropriate health and cancer screening in PAWH.

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来源期刊
Journal of Frailty & Aging
Journal of Frailty & Aging GERIATRICS & GERONTOLOGY-
CiteScore
5.90
自引率
7.70%
发文量
54
期刊介绍: The Journal of Frailty & Aging is a peer-reviewed international journal aimed at presenting articles that are related to research in the area of aging and age-related (sub)clinical conditions. In particular, the journal publishes high-quality papers describing and discussing social, biological, and clinical features underlying the onset and development of frailty in older persons.          The Journal of Frailty & Aging is composed by five different sections: - Biology of frailty and aging In this section, the journal presents reports from preclinical studies and experiences focused at identifying, describing, and understanding the subclinical pathophysiological mechanisms at the basis of frailty and aging. - Physical frailty and age-related body composition modifications Studies exploring the physical and functional components of frailty are contained in this section. Moreover, since body composition plays a major role in determining physical frailty and, at the same time, represents the most evident feature of the aging process, special attention is given to studies focused on sarcopenia and obesity at older age. - Neurosciences of frailty and aging The section presents results from studies exploring the cognitive and neurological aspects of frailty and age-related conditions. In particular, papers on neurodegenerative conditions of advanced age are welcomed. - Frailty and aging in clinical practice and public health This journal’s section is devoted at presenting studies on clinical issues of frailty and age-related conditions. This multidisciplinary section particularly welcomes reports from clinicians coming from different backgrounds and specialties dealing with the heterogeneous clinical manifestations of advanced age. Moreover, this part of the journal also contains reports on frailty- and age-related social and public health issues. - Clinical trials and therapeutics This final section contains all the manuscripts presenting data on (pharmacological and non-pharmacological) interventions aimed at preventing, delaying, or treating frailty and age-related conditions.The Journal of Frailty & Aging is a quarterly publication of original papers, review articles, case reports, controversies, letters to the Editor, and book reviews. Manuscripts will be evaluated by the editorial staff and, if suitable, by expert reviewers assigned by the editors. The journal particularly welcomes papers by researchers from different backgrounds and specialities who may want to share their views and experiences on the common themes of frailty and aging.The abstracting and indexing of the Journal of Frailty & Aging is covered by MEDLINE (approval by the National Library of Medicine in February 2016).
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