糖尿病视网膜的血流分布和内皮表面层。

IF 1 4区 医学 Q4 BIOPHYSICS
Biorheology Pub Date : 2019-01-01 DOI:10.3233/BIR-180200
Norman R Harris, Wendy Leskova, Gaganpreet Kaur, Randa S Eshaq, Patsy R Carter
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引用次数: 7

摘要

糖尿病视网膜病变被认为是高血糖的微血管并发症,伴有血液-视网膜屏障的破坏、周细胞的丧失、微出血的形成、早期灌注减少和局部缺血,推测后者可诱导疾病的最终增生、血管生成阶段。我们的糖尿病视网膜病变动物模型显示出与人类糖尿病早期相似的视网膜血流量减少。我们的研究还显示视网膜红细胞分布的改变,深层毛细血管层接受的比例减少,血流更多地转向浅层血管层。正常的红细胞分布依赖于内皮表面层的存在,特别是糖萼,据报道,在人类和动物的糖尿病视网膜中,糖萼部分丢失。本文综述了糖尿病的两种现象:灌注模式改变和糖萼丢失,两者之间可能存在联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Blood flow distribution and the endothelial surface layer in the diabetic retina.

Blood flow distribution and the endothelial surface layer in the diabetic retina.

Blood flow distribution and the endothelial surface layer in the diabetic retina.

Diabetic retinopathy is known as a microvascular complication of hyperglycemia, with a breakdown of the blood-retinal barrier, loss of pericytes, formation of microhemorrhages, early decreases in perfusion and areas of ischemia, with the latter speculated to induce the eventual proliferative, angiogenic phase of the disease. Our animal models of diabetic retinopathy demonstrate similar decreases in retinal blood flow as seen in the early stages of diabetes in humans. Our studies also show an alteration in the retinal distribution of red blood cells, with the deep capillary layer receiving a reduced fraction, and with flow being diverted more towards the superficial vascular layer. Normal red blood cell distribution is dependent on the presence of the endothelial surface layer, specifically the glycocalyx, which has been reported to be partially lost in the diabetic retina of both humans and animals. This review addresses these two phenomena in diabetes: altered perfusion patterns and loss of the glycocalyx, with a possible connection between the two.

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来源期刊
Biorheology
Biorheology 医学-工程:生物医学
CiteScore
2.00
自引率
0.00%
发文量
5
审稿时长
>12 weeks
期刊介绍: Biorheology is an international interdisciplinary journal that publishes research on the deformation and flow properties of biological systems or materials. It is the aim of the editors and publishers of Biorheology to bring together contributions from those working in various fields of biorheological research from all over the world. A diverse editorial board with broad international representation provides guidance and expertise in wide-ranging applications of rheological methods to biological systems and materials. The scope of papers solicited by Biorheology extends to systems at different levels of organization that have never been studied before, or, if studied previously, have either never been analyzed in terms of their rheological properties or have not been studied from the point of view of the rheological matching between their structural and functional properties. This biorheological approach applies in particular to molecular studies where changes of physical properties and conformation are investigated without reference to how the process actually takes place, how the forces generated are matched to the properties of the structures and environment concerned, proper time scales, or what structures or strength of structures are required.
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