斯洛伐克妇女桥本病的维生素D不足与甲状腺自身免疫无关。

IF 1.5 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Lenka Filipova, Zora Lazurova, Pavol Fulop, Ivica Lazurova
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引用次数: 1

摘要

维生素D (VD)在自身免疫性疾病(AI)发病机制中的作用被广泛研究。然而,其与自身免疫性甲状腺疾病(AITD)的关系仍存在争议。本研究的目的是评估斯洛伐克绝经前新诊断为AITD的妇女维生素D水平与甲状腺自身免疫之间的关系。对象和方法:这项前瞻性病例对照研究包括57名患有AITD的女性和41名年龄和bmi匹配的对照组。所有受试者均检测夏季和冬季血清25(OH)D、甲状腺自身抗体(a-TPO、a-TG)、游离et4和TSH浓度。超声测量甲状腺体积。结果:AITD组与对照组血清25(OH)D水平无显著差异。25(OH)D和甲状腺自身抗体之间没有明显的相关性,无论是在整个队列中还是在AITD妇女中。AITD妇女维生素D不足的发生率为60.31%,对照组为52.5%。本研究未发现VD与甲状腺自身抗体、甲状腺激素和甲状腺体积有显著相关性。结论:作者得出结论,VD功能不全在斯洛伐克绝经前妇女中很常见,独立于AITD的存在。早期诊断为AITD的患者,维生素D缺乏与甲状腺自身免疫无关(表3,文献31)。关键词:维生素D,自身免疫性甲状腺疾病,甲状腺自身抗体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vitamin D insufficiency is not associated with thyroid autoimmunity in Slovak women with Hashimoto´s disease.

The role of vitamin D (VD) in the etiopathogenesis of autoimmune diseases (AI) is extensively studied. However, its association with autoimmune thyroid disease (AITD) is still controversial. AIM of this study was to assess the relationship between the vitamin D status and thyroid autoimmunity in Slovak premenopausal women with newly diagnosed AITD.

Subjects and methods: This prospective case-control study included 57 women with AITD and 41 age- and BMI-matched controls. All subjects were examined for summer and winter serum 25(OH)D, thyroid autoantibodies (a-TPO, a-TG), freeT4 and TSH concentrations. Thyroid volume was measured by ultrasound.

Results: There were no significant differences in serum 25(OH)D between AITD and control groups. No significant correlation between 25(OH)D and thyroid autoantibodies was found either in the whole cohort or in AITD women. The prevalence of vitamin D insufficiency was 60.31 % in AITD women and 52.5 % in the control group. No significant association between VD and thyroid autoantibodies, thyroid hormones and thyroid volume was detected in this study.

Conclusion: Authors conclude that VD insufficiency is common in Slovak premenopausal women independently of the presence of AITD. Vitamin D insufficiency is not associated with thyroid autoimmunity in patients with early diagnosis of AITD (Tab. 3, Ref. 31). Text in PDF www.elis.sk Keywords: vitamin D, autoimmune thyroid disease, thyroid autoantibodies.

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来源期刊
CiteScore
2.60
自引率
0.00%
发文量
185
审稿时长
3-8 weeks
期刊介绍: The international biomedical journal - Bratislava Medical Journal – Bratislavske lekarske listy (Bratisl Lek Listy/Bratisl Med J) publishes peer-reviewed articles on all aspects of biomedical sciences, including experimental investigations with clear clinical relevance, original clinical studies and review articles.
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