神经元芯片:神经组织培养微流体系统的设计与使用综述》。

IF 17.2 1区 工程技术 Q1 ENGINEERING, BIOMEDICAL
David Choy Buentello;Mariana García-Corral;Grissel Trujillo-de Santiago;Mario Moisés Alvarez
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引用次数: 2

摘要

神经元芯片(NoC)系统--培养神经元的微流控设备--已成为替代动物模型或最大限度减少动物模型使用的一种有前途的替代方法,并极大地促进了体外研究。在此,我们回顾并讨论了神经元芯片平台的当前发展,特别强调了现有的生物模型、培养技术、生物材料和拓扑结构。我们还讨论了结构、流动和梯度如何影响神经元的生长、分化和发育。最后,我们还讨论了 NoCs 在基础研究(即电、机械/拓扑或化学刺激效应研究)和疾病建模中的一些最新应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neuron(s)-on-a-Chip: A Review of the Design and Use of Microfluidic Systems for Neural Tissue Culture
Neuron-on-chip (NoC) systems—microfluidic devices in which neurons are cultured—have become a promising alternative to replace or minimize the use of animal models and have greatly facilitated in vitro research. Here, we review and discuss current developments in neuron-on-chip platforms, with a particular emphasis on existing biological models, culturing techniques, biomaterials, and topologies. We also discuss how the architecture, flow, and gradients affect neuronal growth, differentiation, and development. Finally, we discuss some of the most recent applications of NoCs in fundamental research (i.e., studies on the effects of electrical, mechanical/topological, or chemical stimuli) and in disease modeling.
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来源期刊
IEEE Reviews in Biomedical Engineering
IEEE Reviews in Biomedical Engineering Engineering-Biomedical Engineering
CiteScore
31.70
自引率
0.60%
发文量
93
期刊介绍: IEEE Reviews in Biomedical Engineering (RBME) serves as a platform to review the state-of-the-art and trends in the interdisciplinary field of biomedical engineering, which encompasses engineering, life sciences, and medicine. The journal aims to consolidate research and reviews for members of all IEEE societies interested in biomedical engineering. Recognizing the demand for comprehensive reviews among authors of various IEEE journals, RBME addresses this need by receiving, reviewing, and publishing scholarly works under one umbrella. It covers a broad spectrum, from historical to modern developments in biomedical engineering and the integration of technologies from various IEEE societies into the life sciences and medicine.
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