同种异体肾移植栓塞失败在治疗移植物不耐受综合征中的作用。

IF 1.1 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Clinical Imaging Science Pub Date : 2023-01-01 DOI:10.25259/JCIS_109_2022

Hussam Hindi, Ali Harb

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引用次数: 0

摘要

近20%的同种异体肾移植在5年后失败，导致再次进行血液透析。这些患者随后接受免疫抑制治疗，失败的同种异体移植物留在原位。然而，许多患者(40%)出现移植物不耐受综合征，以发热、疼痛和血尿为特征。传统上，这是通过低剂量维持免疫抑制剂治疗来管理的，然而，这并非没有明显的不良风险。对于难治性患者，移植肾切除术是治疗的首选;然而，这种疾病的发病率和死亡率都很高。介入放射学在治疗移植物不耐受综合征中起着重要作用，同时改善了患者的预后。

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Role of failed renal allograft embolization in the treatment of graft intolerance syndrome.

Nearly, 20% of renal allografts fail after 5 years resulting in a return to hemodialysis. These patients subsequently undergo withdrawal of immunosuppressant therapy, and the failed allograft is left in situ. However, many patients (40%) develop graft intolerance syndrome, characterized by fever, pain, and hematuria. Conventionally, this is managed with low-dose maintenance immunosuppressant therapy, however, that is not without notable adverse risk. In refractory patients, transplant nephrectomy is the treatment of choice; however, this caries significant morbidity and mortality. Interventional radiology plays a substantial role of treating graft intolerance syndrome while delivering improved patient outcomes.

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来源期刊

Journal of Clinical Imaging Science RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

2.00

自引率

0.00%

发文量

期刊介绍： The Journal of Clinical Imaging Science (JCIS) is an open access peer-reviewed journal committed to publishing high-quality articles in the field of Imaging Science. The journal aims to present Imaging Science and relevant clinical information in an understandable and useful format. The journal is owned and published by the Scientific Scholar. Audience Our audience includes Radiologists, Researchers, Clinicians, medical professionals and students. Review process JCIS has a highly rigorous peer-review process that makes sure that manuscripts are scientifically accurate, relevant, novel and important. Authors disclose all conflicts, affiliations and financial associations such that the published content is not biased.