波斯语版阿尔茨海默病行为病理学量表（BEHAVE-AD）和经验 BHAVE-AD （E-BEHAVE-AD）的验证研究。

IF 1.4 4区心理学 Q4 CLINICAL NEUROLOGY

Applied Neuropsychology-Adult Pub Date : 2025-03-01 Epub Date: 2023-02-11 DOI:10.1080/23279095.2023.2175680

Maryam Noroozian, Zahra Vahabi, Zahra Hooshyari, Farnaz Etesam, Helya Tarighatnia

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引用次数: 0

摘要

简介90%以上的阿尔茨海默病（AD）患者都会出现痴呆的行为和心理症状（BPSD）。如果能及早发现并采取适当措施，这些症状是可以治愈的。阿尔茨海默病行为病理评定量表（BEHAVE-AD）和经验 BEHAVE-AD（E-BEHAVE-AD）旨在识别 BPSD。本研究的目的是验证 BEHAVE-AD 和 E-BEHAVE-AD 的波斯语版本，并为临床和研究应用做好准备：方法：通过有意抽样和便利抽样相结合的方式，选取 120 名患者。所有参与者均应符合 NINCDS-ADRDA 工作组的阿尔茨海默病临床诊断标准。功能评估分期工具（FAST）用于确定阿尔茨海默病的进展速度。使用 BEHAVE-AD 和 E-BEHAVE-AD 问卷以及波斯语版神经精神量表问卷 (NPI-Q) 和迷你精神状态检查 (MMSE) 对所有患者进行评估。内容效度指数（CVI）是根据专家小组的意见，根据两个量表的波斯语版本和原始版本的兼容性确定的。MMSE与BEHAVE-AD和E-BEHAVE-AD的相关性以及FAST的AD进展连续体上的BPSD模式被视为构造效度的指标。通过将 NPI-Q 评分与 BEHAVE-AD 和 E-BEHAVE-AD 评分相关联来评估并发效度。对于这两个量表，研究人员之间的信度被提取出来作为信度指标：BEHAVE-AD 量表的皮尔逊相关系数如下：与 NPI-Q（r = 0.77，p 值 r = -0.34，p 值 r = 0.59，p 值 r = 0.31，p 值 p 值 p 值结论：BEHAVE-AD 量表与 NPI-Q 量表的皮尔逊相关系数如下：与 NPI-Q 量表（r = 0.77，p 值 r = -0.34，p 值 r = 0.59，p 值 r = 0.31，p 值 p 值 p 值 p 值 p 值波斯语版 BEHAVE-AD 和 E-BEHAVE-AD 对评估 AD 患者的 BPSD 有效且可靠。

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Validation study of the Persian version of behavioral pathology in Alzheimer's Disease Rating scale (BEHAVE-AD) and the empirical BHAVE-AD (E-BEHAVE-AD).

Introduction: Behavioral and psychological symptoms of dementia (BPSD) are observed in more than 90% of patients with Alzheimer's disease (AD). BPSDs are remediable if detected early and managed appropriately. Behavioral Pathology in Alzheimer's disease Rating Scale (BEHAVE-AD) and Empirical BEHAVE-AD (E-BEHAVE-AD) were designed to identify BPSD. The aim of this study is to validate and prepare BEHAVE-AD and E-BEHAVE-AD in Persian language for clinical and research applications.

Method: 120 patients were selected through a combination of intentional and convenience sampling. All participants should fulfill the NINCDS-ADRDA Work Group criteria for a clinical diagnosis of Alzheimer's disease. Functional Assessment Staging Tool (FAST) was used to determine the rate of AD progression. All patients were evaluated using the BEHAVE-AD and E-BEHAVE-AD questionnaires, as well as the Persian version of the Neuropsychiatric Inventory Questionnaire (NPI-Q) and Mini-Mental State Examination (MMSE). The Content Validity Index (CVI) is determined based on the compatibility of the Persian and the original version of the two scales according to the opinion of expert panels. Correlation of MMSE with BEHAVE-AD and E-BEHAVE-AD as well as the BPSD pattern on AD progression continuum by FAST were considered as indices of construct validity. Concurrent validity was estimated by correlating NPI-Q scores with BEHAVE-AD and E-BEHAVE-AD scores. For both scales, interrater reliability was extracted as a reliability index.

Results: Pearson correlation coefficients for the BEHAVE-AD scale were as follows: with NPI-Q (r = 0.77, p-value <0.01), with MMSE (r = -0.34, p-value <0.01), indicating concurrent and construct validity, respectively. The result for E-BEHAVE-AD was as follows: with NPI-Q-total (r = 0.59, p-value <0.01), and with MMSE (r = 0.31, p-value <0. 01). BEHAVE-AD and E-BEHAVE-AD scores increased in parallel with AD severity according to FAST, but not on the most severe AD stage. The area under the curve was estimated to be 0.84 (p-value <0.001) for BEHAVE-AD and 0.78 (p-value <0.001) for E-BEHAVE-AD. Correlation between BEHAVE-AD and E-BEHAVE-AD scores ranged from 0.45 to 0.63. The inter-rater reliability index ranged from 0.88 to 0.99 for BEHAVE-AD and from 0.74 to 0.95 for E-BEHAVE-AD.

Conclusions: The Persian version of BEHAVE-AD and E-BEHAVE-AD is valid and reliable for the assessment of BPSD in patients with AD.

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来源期刊

Applied Neuropsychology-Adult CLINICAL NEUROLOGY-PSYCHOLOGY

CiteScore

4.50

自引率

11.80%

发文量

134

期刊介绍： pplied Neuropsychology-Adult publishes clinical neuropsychological articles concerning assessment, brain functioning and neuroimaging, neuropsychological treatment, and rehabilitation in adults. Full-length articles and brief communications are included. Case studies of adult patients carefully assessing the nature, course, or treatment of clinical neuropsychological dysfunctions in the context of scientific literature, are suitable. Review manuscripts addressing critical issues are encouraged. Preference is given to papers of clinical relevance to others in the field. All submitted manuscripts are subject to initial appraisal by the Editor-in-Chief, and, if found suitable for further considerations are peer reviewed by independent, anonymous expert referees. All peer review is single-blind and submission is online via ScholarOne Manuscripts.