低温等离子体作为区分善恶的魔杖。

IF 3.6 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Shinya Toyokuni, Hao Zheng, Yingyi Kong, Kotaro Sato, Kae Nakamura, Hiromasa Tanaka, Yasumasa Okazaki
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引用次数: 1

摘要

等离子体是物质的第四种物理状态,其特征是电离的气体混合物,仅次于固相、液相和气相,并包含各种成分,如离子、电子、自由基和紫外线。太阳和雷电是典型的天然等离子体,而最近电子学的进展使体温等离子体的产生成为可能,自20世纪90年代以来被称为低温等离子体(LTP)或非热等离子体。LTP在生物学和医学上的应用已经引起了研究人员的注意。地球上所有的生物都利用水作为溶剂和分子运输的基本介质。因此,无论LTP直接或间接暴露,LTP的生物应用都会自然地干预水,其中血浆活化乳酸(PAL)是标准,含有H2O2, NO2-和其他已识别的分子。电子自旋共振和免疫组织化学研究表明,LTP暴露是一种方便的方法来加载局部氧化应激。癌细胞的特点是持续的自我复制和高的胞质催化铁(II)。因此,与非肿瘤细胞相比,直接暴露于LTP和PAL均可对癌细胞造成更高的损伤,这一点已在多种癌症类型中得到证实。根据肿瘤类型不同,细胞死亡方式为细胞凋亡或铁下垂。因此,LTP和PAL有望作为既定指导方案的额外癌症治疗,特别是用于躯体腔或手术边缘。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Low-temperature plasma as magic wand to differentiate between the good and the evil.

Plasma is the fourth physical state of matter, characterized by an ionized gaseous mixture, after solid, liquid, and gas phases, and contains a wide array of components such as ions, electrons, radicals, and ultraviolet ray. Whereas the sun and thunder are typical natural plasma, recent progress in the electronics enabled the generation of body-temperature plasma, designated as low-temperature plasma (LTP) or non-thermal plasma since the 1990s. LTP has attracted the attention of researchers for possible biological and medical applications. All the living species on earth utilize water as essential media for solvents and molecular transport. Thus, biological application of LTP naturally intervenes water whether LTP is exposed directly or indirectly, where plasma-activated lactate (PAL) is a standard, containing H2O2, NO2- and other identified molecules. Electron spin resonance and immunohistochemical studies demonstrated that LTP exposure is a handy method to load local oxidative stress. Cancer cells are characterized by persistent self-replication and high cytosolic catalytic Fe(II). Therefore, both direct exposure of LTP and PAL can provide higher damage to cancer cells in comparison to non-tumorous cells, which has been demonstrated in a variety of cancer types. The cell death mode is either apoptosis or ferroptosis, depending on the cancer-type. Thus, LTP and PAL are expected to work as an additional cancer therapy to the established guideline protocols, especially for use in somatic cavities or surgical margins.

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来源期刊
Free Radical Research
Free Radical Research 生物-生化与分子生物学
CiteScore
6.70
自引率
0.00%
发文量
47
审稿时长
3 months
期刊介绍: Free Radical Research publishes high-quality research papers, hypotheses and reviews in free radicals and other reactive species in biological, clinical, environmental and other systems; redox signalling; antioxidants, including diet-derived antioxidants and other relevant aspects of human nutrition; and oxidative damage, mechanisms and measurement.
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