Sfrp4 与皮质骨生物学

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Current Osteoporosis Reports Pub Date : 2022-04-01 Epub Date: 2022-02-19 DOI:10.1007/s11914-022-00727-w
Ruiying Chen, Roland Baron, Francesca Gori
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引用次数: 0

摘要

综述的目的:骨膜附着和骨内膜重塑调节皮质骨的扩张和厚度,两者都是决定骨强度的关键因素。然而,调控骨膜和骨内膜的细胞特征和局部或旁分泌因子在很大程度上仍然难以捉摸。在此,我们将通过对Wnt配体的诱饵受体分泌型Frizzled受体蛋白4(Sfrp4)的研究,探讨皮质骨生长、扩张和稳态的新见解:SFRP4功能缺失突变会导致派尔病,这是一种罕见的骨骼疾病,其特点是皮质骨变薄,尽管骨小梁密度增加,但脆性骨折却增加。在骨内膜表面,Sfrp4 介导的非经典 Wnt 信号抑制调节骨内膜吸收。在骨膜上,Sfrp4 是骨膜干细胞/祖细胞扩增和分化的关键功能介质。通过分析调节骨骼干细胞/祖细胞的信号通路,我们有机会加深对皮质骨生物学相关机制的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Sfrp4 and the Biology of Cortical Bone.

Sfrp4 and the Biology of Cortical Bone.

Purpose of review: Periosteal apposition and endosteal remodeling regulate cortical bone expansion and thickness, both critical determinants of bone strength. Yet, the cellular characteristics and local or paracrine factors that regulate the periosteum and endosteum remain largely elusive. Here we discuss novel insights in cortical bone growth, expansion, and homeostasis, provided by the study of Secreted Frizzled Receptor Protein 4 (Sfrp4), a decoy receptor for Wnt ligands.

Recent findings: SFRP4 loss-of function mutations cause Pyle disease, a rare skeletal disorder characterized by cortical bone thinning and increased fragility fractures despite increased trabecular bone density. On the endosteal surface, Sfrp4-mediated repression of non-canonical Wnt signaling regulates endosteal resorption. On the periosteum, Sfrp4 identifies as a critical functional mediator of periosteal stem cell/progenitor expansion and differentiation. Analysis of signaling pathways regulating skeletal stem cells/progenitors provides an opportunity to advance our understanding of the mechanisms involved in cortical bone biology.

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来源期刊
Current Osteoporosis Reports
Current Osteoporosis Reports Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
8.80
自引率
2.30%
发文量
44
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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