认知老化和体育活动的前景。

IF 4 2区医学 Q2 CHEMISTRY, MEDICINAL

ACS Infectious Diseases Pub Date : 2022-05-09 DOI:10.1146/annurev-clinpsy-072720-014213

Kirk I Erickson, Shannon D Donofry, Kelsey R Sewell, Belinda M Brown, Chelsea M Stillman

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引用次数: 36

摘要

认知老化领域是不可避免地与衰退和缺陷有关，还是正在转向强调在晚年保持和增强认知功能的希望?答案的一部分来自于试图理解认知衰退程度和速度的个体差异的原因的研究。有证据表明，一些健康行为可以增强认知能力或减缓与年龄相关的认知能力下降的速度，这一研究成果创造了一种乐观情绪。在此背景下，我们讨论了身体活动对成年后期神经认知功能的作用，并总结了如何将其概念化为维持认知功能的建设性方法，以及如何将其作为增强或优化晚年认知功能的治疗方法。通过这种方式，体育活动研究可以用来塑造对认知衰老的看法。

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Cognitive Aging and the Promise of Physical Activity.

Is the field of cognitive aging irretrievably concerned with decline and deficits, or is it shifting to emphasize the hope of preservation and enhancement of cognitive function in late life? A fragment of an answer comes from research attempting to understand the reasons for individual variability in the extent and rate of cognitive decline. This body of work has created a sense of optimism based on evidence that there are some health behaviors that amplify cognitive performance or mitigate the rate of age-related cognitive decline. In this context, we discuss the role of physical activity on neurocognitive function in late adulthood and summarize how it can be conceptualized as a constructive approach both for the maintenance of cognitive function and as a therapeutic for enhancing or optimizing cognitive function in late life. In this way, physical activity research can be used to shape perceptions of cognitive aging.

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来源期刊

ACS Infectious Diseases CHEMISTRY, MEDICINALINFECTIOUS DISEASES&nb-INFECTIOUS DISEASES

CiteScore

9.70

自引率

3.80%

发文量

213

期刊介绍： ACS Infectious Diseases will be the first journal to highlight chemistry and its role in this multidisciplinary and collaborative research area. The journal will cover a diverse array of topics including, but not limited to: * Discovery and development of new antimicrobial agents — identified through target- or phenotypic-based approaches as well as compounds that induce synergy with antimicrobials. * Characterization and validation of drug target or pathways — use of single target and genome-wide knockdown and knockouts, biochemical studies, structural biology, new technologies to facilitate characterization and prioritization of potential drug targets. * Mechanism of drug resistance — fundamental research that advances our understanding of resistance; strategies to prevent resistance. * Mechanisms of action — use of genetic, metabolomic, and activity- and affinity-based protein profiling to elucidate the mechanism of action of clinical and experimental antimicrobial agents. * Host-pathogen interactions — tools for studying host-pathogen interactions, cellular biochemistry of hosts and pathogens, and molecular interactions of pathogens with host microbiota. * Small molecule vaccine adjuvants for infectious disease. * Viral and bacterial biochemistry and molecular biology.