Tao Gao, Yinan Zheng, Brian T Joyce, Minjung Kho, James G Terry, Jun Wang, Drew Nannini, John Jeffrey Carr, Sangeeta Nair, Kai Zhang, Wei Zhao, David R Jacobs, Pamela J Schreiner, Philip Greenland, Donald Lloyd-Jones, Jennifer A Smith, Lifang Hou
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We used multivariate regression models to examine associations of GAA estimates with muscle imaging measurements.</p><p><strong>Results: </strong>In the CARDIA study, each 1-year higher GAA was associated with an average 1.1% (95% confidence interval [CI]: 0.6%, 1.5%) higher intermuscular adipose tissue (IMAT) volume for abdominal muscles. Each 1-year higher GAA was associated with an average -0.089 Hounsfield unit (HU; 95% CI: -0.146, -0.032) lower lean muscle attenuation and an average -0.049 HU (95% CI: -0.092, -0.007) lower IMAT attenuation for abdominal muscles. Stratified analyses showed that GAA was more strongly associated with higher abdominal muscle IMAT volume in females and significantly associated with lower lean muscle attenuation for White participants only.</p><p><strong>Conclusions: </strong>Higher GAA is associated with higher abdominal muscle IMAT volume and lower lean muscle attenuation in a midlife population.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. 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However, the associations between GAA and muscle mass and function are unknown.</p><p><strong>Methods: </strong>We estimated measures of GAA in 1 118 Black and White participants from the Coronary Artery Risk Development in Young Adults (CARDIA) Study at exam years (Y) 15 (2000-2001) and 20 (2005-2006). Abdominal muscle composition was measured using CT scans at the Y25 (2010-2011) visit. We used multivariate regression models to examine associations of GAA estimates with muscle imaging measurements.</p><p><strong>Results: </strong>In the CARDIA study, each 1-year higher GAA was associated with an average 1.1% (95% confidence interval [CI]: 0.6%, 1.5%) higher intermuscular adipose tissue (IMAT) volume for abdominal muscles. Each 1-year higher GAA was associated with an average -0.089 Hounsfield unit (HU; 95% CI: -0.146, -0.032) lower lean muscle attenuation and an average -0.049 HU (95% CI: -0.092, -0.007) lower IMAT attenuation for abdominal muscles. Stratified analyses showed that GAA was more strongly associated with higher abdominal muscle IMAT volume in females and significantly associated with lower lean muscle attenuation for White participants only.</p><p><strong>Conclusions: </strong>Higher GAA is associated with higher abdominal muscle IMAT volume and lower lean muscle attenuation in a midlife population.</p>\",\"PeriodicalId\":94243,\"journal\":{\"name\":\"The journals of gerontology. Series A, Biological sciences and medical sciences\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10876078/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The journals of gerontology. 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引用次数: 0
摘要
背景:grmage acceleration (GAA)是一种代表生理性衰老的表观遗传标记，与癌症和心血管疾病等年龄相关疾病有关。然而，GAA与肌肉质量和功能之间的关系尚不清楚。方法:我们估计了来自青年冠状动脉风险发展(CARDIA)研究的1118名黑人和白人参与者在考试年(Y) 15(2000-01)和20(2005-06)的GAA测量值。在第25年(2010-11年)就诊时使用CT扫描测量腹部肌肉成分。我们使用多元回归模型来检验GAA估计值与肌肉成像测量值之间的关系。结果:在CARDIA研究中，GAA每增加一年，腹肌肌间脂肪组织(IMAT)体积平均增加1.1% (95% CI 0.6%， 1.5%)。GAA每升高一年，瘦肌衰减平均为-0.089 Hounsfield单位(95% CI -0.146， -0.032)，腹肌IMAT衰减平均为-0.049 HU (95% CI -0.092， -0.007)。分层分析显示，GAA与女性较高的腹肌IMAT体积有更强的相关性，仅白人参与者与较低的瘦肌肉衰减有显著相关性。结论:在中年人群中，较高的GAA与较高的腹肌IMAT体积和较低的瘦肌衰减有关。
Epigenetic Aging Is Associated With Measures of Midlife Muscle Volume and Attenuation in CARDIA Study.
Background: GrimAge acceleration (GAA), an epigenetic marker that represents physiologic aging, is associated with age-related diseases including cancer and cardiovascular diseases. However, the associations between GAA and muscle mass and function are unknown.
Methods: We estimated measures of GAA in 1 118 Black and White participants from the Coronary Artery Risk Development in Young Adults (CARDIA) Study at exam years (Y) 15 (2000-2001) and 20 (2005-2006). Abdominal muscle composition was measured using CT scans at the Y25 (2010-2011) visit. We used multivariate regression models to examine associations of GAA estimates with muscle imaging measurements.
Results: In the CARDIA study, each 1-year higher GAA was associated with an average 1.1% (95% confidence interval [CI]: 0.6%, 1.5%) higher intermuscular adipose tissue (IMAT) volume for abdominal muscles. Each 1-year higher GAA was associated with an average -0.089 Hounsfield unit (HU; 95% CI: -0.146, -0.032) lower lean muscle attenuation and an average -0.049 HU (95% CI: -0.092, -0.007) lower IMAT attenuation for abdominal muscles. Stratified analyses showed that GAA was more strongly associated with higher abdominal muscle IMAT volume in females and significantly associated with lower lean muscle attenuation for White participants only.
Conclusions: Higher GAA is associated with higher abdominal muscle IMAT volume and lower lean muscle attenuation in a midlife population.
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