FGF5。

IF 2.2 3区生物学 Q4 CELL BIOLOGY

Differentiation Pub Date : 2024-09-01 DOI:10.1016/j.diff.2023.10.004

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引用次数: 0

摘要

在哺乳动物中，FGF5是毛发周期的负调节因子。它在毛发周期的生长期后期在毛囊的外根鞘中表达。它作为一种信号分子，介导毛发生长周期从生长期到退行期的过渡。在哺乳动物模型中，自发和工程化的FGF5突变导致长头发表型。在人类中，遗传的FGF5突变导致睫状畸形(长睫毛)。在斑马鱼胚胎中敲低fgf5会导致内耳改变。FGF5表达的改变也与各种人类病理有关。

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FGF5

FGF5 functions as a negative regulator of the hair cycle in mammals. It is expressed in the outer root sheath of hair follicles during the late anagen phase of the hair cycle. It functions as a signaling molecule, mediating the transition of the anagen growth phase to catagen regression phase of the hair cycle. Spontaneous and engineered FGF5 mutations in mammalian animal models result in long hair phenotypes. In humans, inherited FGF5 mutations result in trichomegaly (long eyelashes). Knockdown of fgf5 in zebrafish embryos results in inner ear alterations. Alterations in FGF5 expression are also associated with various human pathologies.

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来源期刊

Differentiation 生物-发育生物学

CiteScore

4.10

自引率

3.40%

发文量

审稿时长

51 days

期刊介绍： Differentiation is a multidisciplinary journal dealing with topics relating to cell differentiation, development, cellular structure and function, and cancer. Differentiation of eukaryotes at the molecular level and the use of transgenic and targeted mutagenesis approaches to problems of differentiation are of particular interest to the journal. The journal will publish full-length articles containing original work in any of these areas. We will also publish reviews and commentaries on topics of current interest. The principal subject areas the journal covers are: • embryonic patterning and organogenesis • human development and congenital malformation • mechanisms of cell lineage commitment • tissue homeostasis and oncogenic transformation • establishment of cellular polarity • stem cell differentiation • cell reprogramming mechanisms • stability of the differentiated state • cell and tissue interactions in vivo and in vitro • signal transduction pathways in development and differentiation • carcinogenesis and cancer • mechanisms involved in cell growth and division especially relating to cancer • differentiation in regeneration and ageing • therapeutic applications of differentiation processes.