血管扩张剂刺激的磷酸化蛋白在恶性肿瘤发展中的作用。

IF 2.3 4区医学 Q3 ONCOLOGY

Current cancer drug targets Pub Date : 2024-01-01 DOI:10.2174/0115680096262439231023110106

Jiandong Gui, Hangsheng Zhou, Hongyuan Wan, Dongjie Yang, Qing Liu, Lijie Zhu, Yuanyuan Mi

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引用次数: 0

摘要

VASP是一种肌动蛋白结合蛋白，包括三个结构域:Enabled/VASP同源1 (EVH1)、EVH2和富含脯氨酸(PRR)。VASP在与细胞骨架调节相关的各种细胞行为中起重要作用。更重要的是，VASP在几种恶性肿瘤的进展中起着关键作用，并与恶性细胞的增殖、侵袭和转移有关。本文就VASP对几种恶性肿瘤发生发展的影响及其机制的研究进展进行综述。本研究为临床分子诊断和分子靶向治疗提供了新的理论依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Role of Vasodilator-stimulated Phosphoproteins in the Development of Malignant Tumors.

Vasodilator-stimulated phosphoprotein (VASP) is an actin-binding protein that includes three structural domains: Enabled/VASP homolog1 (EVH1), EVH2, and proline-rich (PRR). VASP plays an important role in various cellular behaviors related to cytoskeletal regulation. More importantly, VASP plays a key role in the progression of several malignant tumors and is associated with malignant cell proliferation, invasion, and metastasis. Here, we have summarized current studies on the impact of VASP on the development of several malignant tumors and their mechanisms. This study provides a new theoretical basis for clinical molecular diagnosis and molecular targeted therapy.

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来源期刊

Current cancer drug targets 医学-肿瘤学

CiteScore

5.40

自引率

0.00%

发文量

105

审稿时长

1 months

期刊介绍： Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes. Current Cancer Drug Targets publishes original research articles, letters, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer. As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.