一个简洁的，绿色的，改进的可扩展的过程中制备抗血栓剂，替格瑞洛

IF 1.7 4区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Fluorine Chemistry Pub Date : 2023-11-01 DOI:10.1016/j.jfluchem.2023.110207

V. Ravi Kanth , V. Siddaiah , B. Hanumantha Rao , I. V. Subramanyeswara Rao , J. Venkateswarlu , K. V. V. Prasada Rao

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引用次数: 0

摘要

报道了一种改进的、绿色的、无柱层析的、低成本的短路线合成替格瑞洛的工艺，总收率为70%，纯度为99.7%。该工艺基本上不含杂质，如羟基替格瑞洛和氨基替格瑞洛等。除此之外，本方法在控制所有杂质百分比在替格瑞洛所需质量范围内具有高度稳健性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A concise, greener, and improved scalable process for the preparation of an anti-thrombotic agent, Ticagrelor

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A concise, greener, and improved scalable process for the preparation of an anti-thrombotic agent, Ticagrelor

An improved, greener, column chromatography free and cost effective process for the preparation of ticagrelor in short route with an overall yield of 70% and 99.7% purity is reported. The process is substantially free from impurities such as hydroxy ticagrelor and amino ticagrelor, etc. In addition to this, the present process is highly robust in controlling all impurity percentages to be within the desired quality of ticagrelor.

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来源期刊

Journal of Fluorine Chemistry 化学-无机化学与核化学

CiteScore

3.80

自引率

10.50%

发文量

审稿时长

33 days

期刊介绍： The Journal of Fluorine Chemistry contains reviews, original papers and short communications. The journal covers all aspects of pure and applied research on the chemistry as well as on the applications of fluorine, and of compounds or materials where fluorine exercises significant effects. This can include all chemistry research areas (inorganic, organic, organometallic, macromolecular and physical chemistry) but also includes papers on biological/biochemical related aspects of Fluorine chemistry as well as medicinal, agrochemical and pharmacological research. The Journal of Fluorine Chemistry also publishes environmental and industrial papers dealing with aspects of Fluorine chemistry on energy and material sciences. Preparative and physico-chemical investigations as well as theoretical, structural and mechanistic aspects are covered. The Journal, however, does not accept work of purely routine nature. For reviews and special issues on particular topics of fluorine chemistry or from selected symposia, please contact the Regional Editors for further details.