在压力下控制对未来恐惧的侵入性想法

IF 4.3 2区 医学 Q1 NEUROSCIENCES
Stephanie M. Ashton , Tom Smeets , Conny W.E.M. Quaedflieg
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引用次数: 0

摘要

对未来的消极看法可能会滋生不想要的和侵入性的想法。在某种程度上,个体可以控制自己抑制干扰和下调频率的能力。急性应激损害有意抑制,导致入侵频率增加。本研究的目的是通过研究两种主要应激激素去甲肾上腺素和皮质醇的联合和独立作用,来深入了解应激诱导的损伤在故意抑制入侵中的机制。健康参与者(N = 181)在接受马斯特里赫特急性压力测试之前被给予心得安(阻断去甲肾上腺素能反应)、美替拉酮(阻断皮质醇反应)或安慰剂。然后通过想象/不想象任务测量自传式未来恐惧的侵入性想法。结果表明,由于药物和压力的操纵,应激反应成功地改变了。在所有的小组中,反复抑制对未来的恐惧减少了干扰。在整个样本中,随着时间的推移,这种增强的减少与对相关恐惧的焦虑的更大衰减有关。两组在入侵的总频率上没有差异。然而,特质焦虑增加了入侵的总数。我们的研究结果表明,应激激素不影响抑制入侵的能力。然而,我们的结果确实支持了先前将焦虑与记忆控制缺陷联系起来的研究。当使用自传体内容时,未来的研究应该关注个体记忆的质量和特征,以解释在有意记忆控制中观察到的更多变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Controlling intrusive thoughts of future fears under stress

Negative outlooks of our future may foster unwanted and intrusive thoughts. To some extent, individuals have control over their ability to suppress intrusions and downregulate their frequency. Acute stress impairs intentional suppression, leading to an increased frequency of intrusions. The aim of this study was to gain insight into the mechanism underlying stress-induced impairments in intentional suppression of intrusions by investigating the combined and independent roles of the two major stress hormones, noradrenaline and cortisol. Healthy participants (N = 181) were administered propranolol (to block the noradrenergic response), metyrapone (to block the cortisol response), or a placebo before being exposed to the Maastricht Acute Stress Test. Intrusive thoughts of autobiographical future fears were then measured via the Imagine/No-Imagine task. Results demonstrated that the stress response was successfully altered because of the drug and stress manipulations. In all groups, repeated suppression of future fears reduced intrusions. Across the sample, an enhanced decrease over time was associated with greater attenuation of anxiety towards the related fears. The groups did not differ in the total frequency of intrusions. Though, trait anxiety increased the total number of intrusions. Our findings show that stress hormones did not influence the ability to suppress intrusions. However, our results do add support to previous research linking anxiety to memory control deficits. When using autobiographical content, future research should focus on the quality and characteristics of the individual memories to explain more of the variation observed in intentional memory control.

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来源期刊
Neurobiology of Stress
Neurobiology of Stress Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
9.40
自引率
4.00%
发文量
74
审稿时长
48 days
期刊介绍: Neurobiology of Stress is a multidisciplinary journal for the publication of original research and review articles on basic, translational and clinical research into stress and related disorders. It will focus on the impact of stress on the brain from cellular to behavioral functions and stress-related neuropsychiatric disorders (such as depression, trauma and anxiety). The translation of basic research findings into real-world applications will be a key aim of the journal. Basic, translational and clinical research on the following topics as they relate to stress will be covered: Molecular substrates and cell signaling, Genetics and epigenetics, Stress circuitry, Structural and physiological plasticity, Developmental Aspects, Laboratory models of stress, Neuroinflammation and pathology, Memory and Cognition, Motivational Processes, Fear and Anxiety, Stress-related neuropsychiatric disorders (including depression, PTSD, substance abuse), Neuropsychopharmacology.
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