{"title":"淋巴细胞中性粒细胞指数是严重脑外伤患者死亡率的相关因素","authors":"Gustavo Adolfo Vásquez-Tirado , Nathali Elena Roldan-Mori , Mayra Milagros Roldan-Mori , Diego Jhosep Alva-Medina , Claudia Vanessa Quispe-Castañeda , Edinson Dante Meregildo-Rodríguez , Niler Manuer Segura-Plasencia , Yessenia Katherin Arbayza-Avalos , Luis Ángel Rodríguez-Chávez , Melissa Ysabel Romero-Díaz , José Cabanillas-López , Hugo Alva-Guarniz , Sussy Yolanda Torres-García , Fabian Roldan-Mori","doi":"10.1016/j.mcpsp.2023.100403","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To determine if the neutrophil-lymphocyte index is a factor associated with mortality in patients with severe traumatic brain injury. In order to establish a rapid marker of unfavorable evolution and adverse outcomes in these patients.</p></div><div><h3>Material and methods</h3><p>The clinical history of 238 patients with severe traumatic brain injury treated in the Intensive Care Unit of the Trujillo Regional Teaching Hospital during the period 2016-2022 was reviewed.</p></div><div><h3>Results</h3><p>The neutrophil-lymphocyte index did not show a significant association with mortality (HRc 1.97 95% CI 0.82-4.72) (p<!--> <!-->><!--> <!-->0.5). The bivariate and multivariate analysis where the intervention of other variables was associated, determined that anisocoria increased the risk of death by 4 times (HRc 4.1; IC95%; 1.86-9.04) (p<!--> <!--><<!--> <!-->0.001), shock increased the risk of death by 6 times. Death (HRc 6.64; 95%; CI 2.49-17.73) (p<!--> <!--><<!--> <!-->0.001), and hypernatremia doubled the risk of death (HRc 2.24; 95%; CI 1.005-4.82) (p<!--> <!--><<!--> <!-->0.04).</p></div><div><h3>Conclusions</h3><p>It was found that anisocoria, shock, hospital stay and Glasgow coma scale at admission are independent predictors of mortality.</p></div>","PeriodicalId":36921,"journal":{"name":"Medicina Clinica Practica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2603924923000411/pdfft?md5=1250f89297d3a58d5487cfcded06c891&pid=1-s2.0-S2603924923000411-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Índice neutrófilo linfocito como factor asociado a la mortalidad en los pacientes con trauma craneoencefálico grave\",\"authors\":\"Gustavo Adolfo Vásquez-Tirado , Nathali Elena Roldan-Mori , Mayra Milagros Roldan-Mori , Diego Jhosep Alva-Medina , Claudia Vanessa Quispe-Castañeda , Edinson Dante Meregildo-Rodríguez , Niler Manuer Segura-Plasencia , Yessenia Katherin Arbayza-Avalos , Luis Ángel Rodríguez-Chávez , Melissa Ysabel Romero-Díaz , José Cabanillas-López , Hugo Alva-Guarniz , Sussy Yolanda Torres-García , Fabian Roldan-Mori\",\"doi\":\"10.1016/j.mcpsp.2023.100403\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>To determine if the neutrophil-lymphocyte index is a factor associated with mortality in patients with severe traumatic brain injury. In order to establish a rapid marker of unfavorable evolution and adverse outcomes in these patients.</p></div><div><h3>Material and methods</h3><p>The clinical history of 238 patients with severe traumatic brain injury treated in the Intensive Care Unit of the Trujillo Regional Teaching Hospital during the period 2016-2022 was reviewed.</p></div><div><h3>Results</h3><p>The neutrophil-lymphocyte index did not show a significant association with mortality (HRc 1.97 95% CI 0.82-4.72) (p<!--> <!-->><!--> <!-->0.5). The bivariate and multivariate analysis where the intervention of other variables was associated, determined that anisocoria increased the risk of death by 4 times (HRc 4.1; IC95%; 1.86-9.04) (p<!--> <!--><<!--> <!-->0.001), shock increased the risk of death by 6 times. Death (HRc 6.64; 95%; CI 2.49-17.73) (p<!--> <!--><<!--> <!-->0.001), and hypernatremia doubled the risk of death (HRc 2.24; 95%; CI 1.005-4.82) (p<!--> <!--><<!--> <!-->0.04).</p></div><div><h3>Conclusions</h3><p>It was found that anisocoria, shock, hospital stay and Glasgow coma scale at admission are independent predictors of mortality.</p></div>\",\"PeriodicalId\":36921,\"journal\":{\"name\":\"Medicina Clinica Practica\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-11-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2603924923000411/pdfft?md5=1250f89297d3a58d5487cfcded06c891&pid=1-s2.0-S2603924923000411-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medicina Clinica Practica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2603924923000411\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicina Clinica Practica","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2603924923000411","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
目的探讨中性粒细胞淋巴细胞指数是否与重型颅脑损伤患者的死亡率有关。为了在这些患者中建立一个不良进展和不良结局的快速标记。材料与方法回顾2016-2022年在特鲁希略地区教学医院重症监护室治疗的238例重型颅脑损伤患者的临床病史。结果中性粒细胞淋巴细胞指数与死亡率无显著相关性(HRc 1.97 95% CI 0.82-4.72) (p >0.5)。双变量和多变量分析，其中其他变量的干预是相关的，确定异色性使死亡风险增加了4倍(HRc 4.1;IC95%;1.86-9.04) (p <0.001)，休克使死亡风险增加6倍。死亡(hrc6.64;95%;CI 2.49-17.73, p <0.001)，高钠血症使死亡风险增加一倍(HRc 2.24;95%;CI 1.005-4.82);0.04)。结论异位、休克、住院时间和入院时格拉斯哥昏迷评分是死亡率的独立预测因子。
Índice neutrófilo linfocito como factor asociado a la mortalidad en los pacientes con trauma craneoencefálico grave
Objective
To determine if the neutrophil-lymphocyte index is a factor associated with mortality in patients with severe traumatic brain injury. In order to establish a rapid marker of unfavorable evolution and adverse outcomes in these patients.
Material and methods
The clinical history of 238 patients with severe traumatic brain injury treated in the Intensive Care Unit of the Trujillo Regional Teaching Hospital during the period 2016-2022 was reviewed.
Results
The neutrophil-lymphocyte index did not show a significant association with mortality (HRc 1.97 95% CI 0.82-4.72) (p > 0.5). The bivariate and multivariate analysis where the intervention of other variables was associated, determined that anisocoria increased the risk of death by 4 times (HRc 4.1; IC95%; 1.86-9.04) (p < 0.001), shock increased the risk of death by 6 times. Death (HRc 6.64; 95%; CI 2.49-17.73) (p < 0.001), and hypernatremia doubled the risk of death (HRc 2.24; 95%; CI 1.005-4.82) (p < 0.04).
Conclusions
It was found that anisocoria, shock, hospital stay and Glasgow coma scale at admission are independent predictors of mortality.
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