接受 19 毫米 Mosaic 治疗的主动脉瓣狭窄患者的左心室重塑和长期预后。

IF 1.1 4区 医学 Q4 ENGINEERING, BIOMEDICAL
Journal of Artificial Organs Pub Date : 2024-03-01 Epub Date: 2023-03-29 DOI:10.1007/s10047-023-01390-3
Daijiro Hori, Takahiro Yamamoto, Naoyuki Kimura, Atsushi Yamaguchi
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引用次数: 0

摘要

在术后超声心动图中,Mosaic 瓣膜在主动脉瓣置换术后显示出的压力梯度高于其他相同尺寸的人工瓣膜。本研究旨在评估接受 19 毫米 Mosaic 瓣膜的患者的中期超声心动图结果和长期临床疗效。接受 19 毫米 Mosaic 移植的 46 名主动脉瓣狭窄患者和接受 19 毫米 Magna 或 Inspiris 移植的 112 名患者接受了中期超声心动图随访。对经胸超声心动图评估的中期血液动力学测量结果和长期疗效进行了比较。接受 Mosaic 治疗的患者年龄明显较大(Mosaic:76 ± 5.1 岁 vs Magna/Inspiris:74 ± 5.5 岁,p = 0.046),体表面积较小(Mosaic:1.40 ± 0.114 平方米 vs Magna/Inspiris:1.48 ± 0.143 平方米,p = 0.046)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Left ventricular remodeling and long-term outcomes of aortic stenosis patients receiving 19 mm Mosaic.

Left ventricular remodeling and long-term outcomes of aortic stenosis patients receiving 19 mm Mosaic.

Mosaic valve shows higher pressure gradient after aortic valve replacement compared to other same size labeled prostheses in postoperative echocardiogram. The purpose of this study was to evaluate the mid-term echocardiogram findings and long-term clinical outcomes of patients receiving a 19 mm Mosaic. Forty-six aortic stenosis patients receiving 19 mm Mosaic and 112 patients receiving either 19 mm Magna or Inspiris, who underwent mid-term follow-up echocardiogram were included in the study. Mid-term hemodynamic measurements evaluated by trans-thoracic echocardiogram and long-term outcomes were compared. Patients receiving Mosaic were significantly older (Mosaic: 76 ± 5.1 years vs. Magna/Inspiris: 74 ± 5.5 years, p = 0.046) and had smaller body surface area (Mosaic: 1.40 ± 0.114m2 vs. Magna/Inspiris: 1.48 ± 0.143m2, p < 0.001). There were no significant differences in comorbidities and medications. Post-operative echocardiogram performed at 1 week after the surgery showed higher maximum pressure gradient in patients receiving Mosaic (Mosaic: 38 ± 13.5 mmHg vs. Magna/Inspiris: 31 ± 10.7 mmHg, p = 0.002). Furthermore, mid-term echocardiogram follow-up performed at median duration of 53 ± 14.9 months after the surgery continuously showed higher maximum pressure gradient in patients receiving Mosaic (Mosaic: 45 ± 15.6 mmHg vs. Magna/Inspiris: 32 ± 13.0 mmHg, p < 0.001). However, there were no significant difference in changes in left ventricular mass from baseline in both groups. Kaplan-Meyer curve also showed no difference in long-term mortality and major adverse cardiac and cerebrovascular event between the two groups. Although the pressure gradient across the valve evaluated by echocardiogram was higher in 19 mm Mosaic compared to 19 mm Magna/Inspiris, there were no significant differences in left ventricular remodeling and long-term outcomes between the two groups.

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来源期刊
Journal of Artificial Organs
Journal of Artificial Organs 医学-工程:生物医学
CiteScore
2.80
自引率
15.40%
发文量
68
审稿时长
6-12 weeks
期刊介绍: The aim of the Journal of Artificial Organs is to introduce to colleagues worldwide a broad spectrum of important new achievements in the field of artificial organs, ranging from fundamental research to clinical applications. The scope of the Journal of Artificial Organs encompasses but is not restricted to blood purification, cardiovascular intervention, biomaterials, and artificial metabolic organs. Additionally, the journal will cover technical and industrial innovations. Membership in the Japanese Society for Artificial Organs is not a prerequisite for submission.
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