A.M Makumyaviri , M Sileghem , D Le Ray , R Hamers , P de Baetselier
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Systéme lymphocytaire et résistance relative de la souris consanguine a Trypanosoma brucei brucei
The distribution of B-(Ig+) and T-(Thy1.2+, Lyt1+, Lyt2+) lymphocyte subsets in murine lymphoid organs was analysed by immunofluorescence (FACS) on cell suspensions throughout a primary infection of C3H/He (susceptible) and CBA/Ca (subtolerant) inbred mice with metacyclic Trypanosoma brucei brucei EATRO 1125.
A direct correlation was observed between (1) the level of first-peak parasitaemia, (2) its subsequent control by the host and (3) survival time.
In the course of the infection, the overall population of spleen and lymph node lymphocytes was subject to polyclonal activation whilst the proportion of differenciated B and T subsets decreased accordingly.
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