Lenka Vargová , Kateřina Vymazalová , Ivana Jarošová , Ivo Mařík , Ladislava Horáčková , František Trampota , Katharina Rebay-Salisbury , Barbara Rendl , Fabian Kanz , Denisa Zlámalová
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引用次数: 0
摘要
目的对多发性骨骺发育不良（MED）的考古和临床鉴别诊断做出贡献。材料来自Drnholec Pod sýpkou（捷克共和国）移民晚期墓地的一具30至45岁男性（墓号806）的骨骼，放射性碳年代为公元492-530年。方法形态和度量分析。结果髋关节和股骨近端有明显的病理变化，与Legg-Calvé-Perthes病的病理变化相似。X光检查可以排除假性软骨发育不全、软骨病和代谢性骨病。结论该发现被认为是先天性多发性骨骺发育不良的可能病例。值得注意的是，该病例将有助于构建对该疾病在历史人群中发生率的估计，并对当前医疗实践中的诊断具有指导意义。局限性由于缺乏基因分析，最终诊断受到限制。对未来研究的建议进一步澄清导致诊断将受益于整个欧洲骨骼遗骸的基因分析和评估。
A case of congenital multiple epiphyseal dysplasia from the Late Migration Period graveyard in Drnholec (Czech Republic)
Objective
To contribute to differential diagnosis of multiple epiphyseal dysplasia (MED) in archeological and clinical contexts.
Materials
A skeleton of a 30- to 45-year-old male (grave no. 806) from the Late Migration Period graveyard in Drnholec-Pod sýpkou (Czech Republic), radio-carbon dated to AD 492–530.
Methods
Morphological and metric analyses.
Results
Significant pathological changes were noted on ossa coxae and proximal ends of the femora, which appear similar to changes associated with Legg-Calvé-Perthes disease. X-ray examination made it possible to rule out pseudoachondroplasia, rickets and metabolic bone diseases.
Conclusions
The finding was evaluated as a probable case of congenital multiple epiphyseal dysplasia.
Significance
This case will contribute to the construction of estimates of the occurrence of this disease in historical populations and can be instructive for diagnostics in current medical practice.
Limitations
The final diagnosis is limited by the lack of genetic analysis.
Suggestion for the future research
Further clarification leading to diagnosis will benefit from genetic analysis and evaluation of skeletal remains throughout Europe.
期刊介绍：
Paleopathology is the study and application of methods and techniques for investigating diseases and related conditions from skeletal and soft tissue remains. The International Journal of Paleopathology (IJPP) will publish original and significant articles on human and animal (including hominids) disease, based upon the study of physical remains, including osseous, dental, and preserved soft tissues at a range of methodological levels, from direct observation to molecular, chemical, histological and radiographic analysis. Discussion of ways in which these methods can be applied to the reconstruction of health, disease and life histories in the past is central to the discipline, so the journal would also encourage papers covering interpretive and theoretical issues, and those that place the study of disease at the centre of a bioarchaeological or biocultural approach. Papers dealing with historical evidence relating to disease in the past (rather than history of medicine) will also be published. The journal will also accept significant studies that applied previously developed techniques to new materials, setting the research in the context of current debates on past human and animal health.
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