Mareike Schulz, Leonie Zieglowski, Marcin Kopaczka, René H Tolba
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引用次数: 0
摘要
简介开阔地试验(OFT)是评估啮齿动物焦虑和行为变化的常用工具。该方法已被应用到猪身上,但尚未对环境变化如何改变猪的表现进行系统研究。目前,在家养猪模型中采用露天野外测试的已发表研究报告数量不断增加,但并未实现标准化:方法:我们的综述旨在调查已发表研究中的开放场地(OF)设置,以及性能与已发表参数之间的相似性:根据 PRISMA 综述指南,我们选择了 69 项研究纳入本系统综述。我们确定了大部分纳入研究的具体设置条件,如尺寸、持续时间和时间;我们发现不同研究在这些测试细节方面存在很大差异:讨论:我们的研究结果表明,测试设置的实施并不一致,包括尺寸、时间、参数和额外的综合测试(如新物体测试)。基于我们的研究结果,我们根据现有文献对 OFT 的性能提出了建议。
The Open Field Test as a Tool for Behaviour Analysis in Pigs: Recommendations for Set-Up Standardization - A Systematic Review.
Introduction: The open field test (OFT) is a common tool to assess anxiety and behavioural changes in rodents. It has been adapted to pigs with no systematic investigation of how environmental changes may alter the performance of pigs. Currently, the number of published studies including the OFT in domestic pig models is increasing without standardization.
Methods: Our review aimed to investigate the open field (OF) set-ups in published studies and the similarities between performance and published parameters.
Results: Following the PRISMA guidelines for reviews, we selected 69 studies for inclusion in this systematic review. We determined the specific set-up conditions such as dimensions, duration, and time of day for most of the included studies; we found high variability across studies with respect to these test specifics.
Discussion: Our results indicate the inconsistent implementation of the set-up, including dimensions, timing, parameters, and additional combined tests (e.g., new object tests). Based on our findings, we have made recommendations for the performance of the OFT, according to the current literature.
期刊介绍:
''European Surgical Research'' features original clinical and experimental papers, condensed reviews of new knowledge relevant to surgical research, and short technical notes serving the information needs of investigators in various fields of operative medicine. Coverage includes surgery, surgical pathophysiology, drug usage, and new surgical techniques. Special consideration is given to information on the use of animal models, physiological and biological methods as well as biophysical measuring and recording systems. The journal is of particular value for workers interested in pathophysiologic concepts, new techniques and in how these can be introduced into clinical work or applied when critical decisions are made concerning the use of new procedures or drugs.