白细胞介素-6水平高与大动脉动脉粥样硬化性卒中有关。

IF 1.1 4区 医学 Q4 CLINICAL NEUROLOGY
Cai Li, Ying Wang, Peina Mei, Tao-Hsin Tung, Gang Wu, Feng Wang, En Wang, Hong Ni, Xingrong Zhu, Zhidi He, Shaofa Ke
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引用次数: 0

摘要

目的:白细胞介素(IL)在调节动脉粥样硬化相关疾病的发生和发展中发挥着重要作用。我们旨在研究ILs与大动脉动脉粥样硬化(LAA)卒中患者的诊断、进展和功能结果之间的关系。方法:对181例首次左心耳卒中患者在卒中后24小时内以及181例年龄匹配和性别匹配的对照组在入院时的血浆IL-2、IL-4、IL-6和IL-10水平进行测量。在入院时以及中风后第1天、第2天、第3天、第4天和第5天记录NIHSS评分。在中风后3个月,通过改良的兰金量表测量功能结果。根据5天内的短期进展(ΔNIHSS≥3)和3个月的不良结果(改良Rankin量表>2)比较亚组分析。对相关混杂因素进行了逻辑回归分析。结果:左心耳卒中患者的IL-6水平高于对照组[AOR(95%CI),0.701(95%CI 0.651-0.748,P结论:左心叶卒中患者的血浆IL-6水平较高,与卒中后的短期进展和3个月的功能结果独立相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High Interleukin-6 Levels Are Associated With Large-Artery Atherosclerotic Stroke.

Objectives: Interleukins (ILs) play several critical roles in modulating the occurrence and development of atherosclerosis-related diseases. We aimed to investigate the associations between ILs and the diagnosis, progress, and functional outcome in patients with large-artery atherosclerotic (LAA) stroke.

Methods: Plasma levels of IL-2, IL-4, IL-6, and IL-10 were measured within 24 hours after stroke in 181 patients with first-time LAA stroke and on admission in 181 age-matched and sex-matched controls. NIHSS scores were recorded at admission and on Day 1, Day 2, Day 3, Day 4, and Day 5 after the stroke. Functional outcome was measured by the modified Rankin Scale at 3 months after stroke. Subgroup analyses were compared based on short-term progress within 5 days (ΔNIHSS ≥3) and 3-month unfavorable outcome (modified Rankin Scale >2). Logistic regression analysis adjusted for relevant confounders was performed.

Results: IL-6 levels were higher in patients with LAA stroke than in controls [AOR (95% CI), 0.701 (95% CI 0.651-0.748, P <0.001], with an area under the receiver operating characteristic curve (AUC) of 0.701. Higher IL-6 levels were associated with short-term progression [AOR (95% CI), 1.070 (1.009, 1.135), P =0.025], with an AUC value of 0.720. Higher IL-6 levels were associated with unfavorable outcomes [AOR (95% CI), 1.075 (1.002, 1.153), P =0.040], with an AUC value of 0.658. No difference in IL-2, IL-4, or IL-10 was found between the groups.

Conclusions: Plasma levels of IL-6 are higher in patients with LAA stroke and are independently associated with short-term progression and 3-month functional outcomes after stroke.

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来源期刊
Neurologist
Neurologist 医学-临床神经学
CiteScore
1.90
自引率
0.00%
发文量
151
审稿时长
2 months
期刊介绍: The Neurologist publishes articles on topics of current interest to physicians treating patients with neurological diseases. The core of the journal is review articles focusing on clinically relevant issues. The journal also publishes case reports or case series which review the literature and put observations in perspective, as well as letters to the editor. Special features include the popular "10 Most Commonly Asked Questions" and the "Patient and Family Fact Sheet," a handy tear-out page that can be copied to hand out to patients and their caregivers.
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