印度西孟加拉邦暴露于人类免疫缺陷病毒的双胎妊娠垂直传播率及其相关因素:一项回顾性队列研究

IF 1.3 4区 医学 Q4 INFECTIOUS DISEASES
Suman Ganguly, Debjit Chakraborty, Sitikantha Banerjee, Falguni Debnath, Subrata Biswas, Agniva Majumdar, Shanta Dutta
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引用次数: 0

摘要

双胎妊娠通常与不良产科结局有关。人类免疫缺陷病毒(HIV)在双胎妊娠中母婴传播的研究较少。因此,本研究旨在确定HIV暴露的双胎妊娠与单胎妊娠的HIV垂直传播风险,并探讨其相关因素。2016年4月至2021年3月,我们通过系统抽样从印度西孟加拉邦的项目数据库中对348名艾滋病毒暴露婴儿(58名双胞胎和290名单胎)进行了回顾性队列研究。比较了单胎和双胎活产婴儿的HIV垂直传播率。确定了产妇年龄、产妇艾滋病毒诊断时间、抗逆转录病毒治疗持续时间、分娩方式、出生体重和婴儿性别等因素的影响。双胎妊娠的HIV传播率(15.5%)显著高于单胎妊娠(5.5%)(校正优势比[OR] = 3.38[1.17-9.69])。在双胎分娩中,产时和产后母体HIV诊断与HIV传播相关(粗OR = 11.0,[2.2-54.9])。围产期艾滋病毒传播在双胎妊娠中更为常见,并且与母体艾滋病毒的检测时间有关。因此,应考虑对双胎妊娠进行早期艾滋病毒检测和额外的抗逆转录病毒治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vertical Transmission Rate of Human Immunodeficiency Virus Exposed Twin Pregnancies and Associated Factors in West Bengal, India: a Retrospective Cohort Study.

Twin pregnancies are often associated with adverse obstetric outcomes. The mother-to-child transmission of the human immunodeficiency virus (HIV) in twin pregnancies has been less explored. Therefore, the present study aimed to determine the risk of vertical transmission of HIV in HIV-exposed twin pregnancies compared with that of singleton pregnancies and to explore the associated factors. We conducted a retrospective cohort study involving 348 HIV-exposed babies (58 twins and 290 singletons) through a systematic sampling from the program database of West Bengal, India, from April 2016 to March 2021. HIV vertical transmission rates were compared between single and twin live births. The effects of factors such as maternal age, timing of maternal HIV diagnosis, duration of antiretroviral treatment, mode of delivery, birth weight, and the sex of the baby were determined. The HIV transmission rate for twin pregnancies (15.5%) was significantly higher than that for single live births (5.5%) (adjusted odds ratio [OR] = 3.38 [1.17-9.69]). Among twin deliveries, maternal HIV diagnosis during the intrapartum and postpartum period was associated with HIV transmission (crude OR = 11.0, [2.2-54.9]). Perinatal HIV transmission is more common in twin pregnancies and is associated with the time of detection of maternal HIV. Therefore, early HIV detection and additional antiretroviral regimens should be considered for twin pregnancies.

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来源期刊
CiteScore
4.50
自引率
4.50%
发文量
172
审稿时长
2 months
期刊介绍: Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.
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