Noé Xiu, Béatrice Vaxelaire, Lanlan Li, Zhenhua Ling, Xiaoya Xu, Linming Huang, Bo Sun, Lin Huang, Rudolph Sock
{"title":"阿尔茨海默病患者嗓音测量研究","authors":"Noé Xiu, Béatrice Vaxelaire, Lanlan Li, Zhenhua Ling, Xiaoya Xu, Linming Huang, Bo Sun, Lin Huang, Rudolph Sock","doi":"10.1016/j.jvoice.2022.08.010","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>As Alzheimer's disease (AD) might provoke certain nerve disorders, patients with AD can acquire sensorimotor adaptation problems, and thus the acoustic characteristics of the speech they produce may differ from those of healthy subjects. This study aimed to (1) extract acoustic characteristics (relating to articulatory gestures) potentially useful for detecting AD and (2) examine whether these characteristics could help identify AD patients.</p><p><strong>Methods: </strong>A total of 50 individuals participated in the study, including the AD group (17 cases), the Neurologically Healthy (NH) group (13 cases), the Mild Cognitive Impairment (MCI) group (11 cases), and the Vascular Cognitive Impairment (VCI) group (9 cases). Voice samples involving three vowels (/i/, /a/, and /u/) and six consonants (/p/, /pʰ/, /t/, /tʰ/, /k/, and /kʰ/) were collected using a digital recorder (TASCAM DR40X). Microphone-to-mouth distance was maintained at 30 cm. Acoustic measures included F0, jitter, shimmer, HNR, F1, F2, F3, and VOT.</p><p><strong>Results: </strong>One-way ANOVA tests were carried out to compare the acoustic measures among the four groups. F3 of vowel /u/, F2 bandwidth of vowel /a/, VOT of consonant /t/, and male participants' F0 of three vowels (/a/, /i/, and /u/) were found significantly different, while no significant differences were found in the other measures.</p><p><strong>Conclusion: </strong>Some acoustic characteristics can indeed help detect AD patients.</p>","PeriodicalId":49954,"journal":{"name":"Journal of Voice","volume":" ","pages":"286.e13-286.e24"},"PeriodicalIF":2.5000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Study on Voice Measures in Patients With Alzheimer's Disease.\",\"authors\":\"Noé Xiu, Béatrice Vaxelaire, Lanlan Li, Zhenhua Ling, Xiaoya Xu, Linming Huang, Bo Sun, Lin Huang, Rudolph Sock\",\"doi\":\"10.1016/j.jvoice.2022.08.010\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>As Alzheimer's disease (AD) might provoke certain nerve disorders, patients with AD can acquire sensorimotor adaptation problems, and thus the acoustic characteristics of the speech they produce may differ from those of healthy subjects. This study aimed to (1) extract acoustic characteristics (relating to articulatory gestures) potentially useful for detecting AD and (2) examine whether these characteristics could help identify AD patients.</p><p><strong>Methods: </strong>A total of 50 individuals participated in the study, including the AD group (17 cases), the Neurologically Healthy (NH) group (13 cases), the Mild Cognitive Impairment (MCI) group (11 cases), and the Vascular Cognitive Impairment (VCI) group (9 cases). Voice samples involving three vowels (/i/, /a/, and /u/) and six consonants (/p/, /pʰ/, /t/, /tʰ/, /k/, and /kʰ/) were collected using a digital recorder (TASCAM DR40X). Microphone-to-mouth distance was maintained at 30 cm. Acoustic measures included F0, jitter, shimmer, HNR, F1, F2, F3, and VOT.</p><p><strong>Results: </strong>One-way ANOVA tests were carried out to compare the acoustic measures among the four groups. F3 of vowel /u/, F2 bandwidth of vowel /a/, VOT of consonant /t/, and male participants' F0 of three vowels (/a/, /i/, and /u/) were found significantly different, while no significant differences were found in the other measures.</p><p><strong>Conclusion: </strong>Some acoustic characteristics can indeed help detect AD patients.</p>\",\"PeriodicalId\":49954,\"journal\":{\"name\":\"Journal of Voice\",\"volume\":\" \",\"pages\":\"286.e13-286.e24\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Voice\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jvoice.2022.08.010\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/9/21 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Voice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jvoice.2022.08.010","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/9/21 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY","Score":null,"Total":0}
A Study on Voice Measures in Patients With Alzheimer's Disease.
Objective: As Alzheimer's disease (AD) might provoke certain nerve disorders, patients with AD can acquire sensorimotor adaptation problems, and thus the acoustic characteristics of the speech they produce may differ from those of healthy subjects. This study aimed to (1) extract acoustic characteristics (relating to articulatory gestures) potentially useful for detecting AD and (2) examine whether these characteristics could help identify AD patients.
Methods: A total of 50 individuals participated in the study, including the AD group (17 cases), the Neurologically Healthy (NH) group (13 cases), the Mild Cognitive Impairment (MCI) group (11 cases), and the Vascular Cognitive Impairment (VCI) group (9 cases). Voice samples involving three vowels (/i/, /a/, and /u/) and six consonants (/p/, /pʰ/, /t/, /tʰ/, /k/, and /kʰ/) were collected using a digital recorder (TASCAM DR40X). Microphone-to-mouth distance was maintained at 30 cm. Acoustic measures included F0, jitter, shimmer, HNR, F1, F2, F3, and VOT.
Results: One-way ANOVA tests were carried out to compare the acoustic measures among the four groups. F3 of vowel /u/, F2 bandwidth of vowel /a/, VOT of consonant /t/, and male participants' F0 of three vowels (/a/, /i/, and /u/) were found significantly different, while no significant differences were found in the other measures.
Conclusion: Some acoustic characteristics can indeed help detect AD patients.
期刊介绍：
The Journal of Voice is widely regarded as the world''s premiere journal for voice medicine and research. This peer-reviewed publication is listed in Index Medicus and is indexed by the Institute for Scientific Information. The journal contains articles written by experts throughout the world on all topics in voice sciences, voice medicine and surgery, and speech-language pathologists'' management of voice-related problems. The journal includes clinical articles, clinical research, and laboratory research. Members of the Foundation receive the journal as a benefit of membership.
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