公共卫生的RNA工程:基于RNA的诊断和治疗的创新。

IF 7.6 2区 工程技术 Q1 CHEMISTRY, APPLIED
Walter Thavarajah, Laura M Hertz, David Z Bushhouse, Chloé M Archuleta, Julius B Lucks
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引用次数: 6

摘要

RNA对细胞功能至关重要:从感知细胞内和细胞外信号到控制基因表达,RNA介导了多种多样的分子过程。合成生物学的一个长期目标是开发RNA工程原理,可用于利用和重新编程这些RNA介导的过程,以设计生物系统来解决紧迫的全球挑战。RNA工程领域的最新进展正在实现这一目标,使基于RNA的工具得以创建,以应对一些最紧迫的公共卫生危机。具体来说,使用工程化rna的新诊断方法能够检测病原体和化学物质,同时产生易于检测的荧光信号作为指示器。新型疫苗和治疗方法也在使用工程化rna来针对广泛的遗传和致病性疾病。在这里,我们讨论了使这些创新成为可能的RNA工程的最新突破,并研究了RNA设计的进步如何有望加速工程RNA系统的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
RNA Engineering for Public Health: Innovations in RNA-Based Diagnostics and Therapeutics.

RNA is essential for cellular function: From sensing intra- and extracellular signals to controlling gene expression, RNA mediates a diverse and expansive list of molecular processes. A long-standing goal of synthetic biology has been to develop RNA engineering principles that can be used to harness and reprogram these RNA-mediated processes to engineer biological systems to solve pressing global challenges. Recent advances in the field of RNA engineering are bringing this to fruition, enabling the creation of RNA-based tools to combat some of the most urgent public health crises. Specifically, new diagnostics using engineered RNAs are able to detect both pathogens and chemicals while generating an easily detectable fluorescent signal as an indicator. New classes of vaccines and therapeutics are also using engineered RNAs to target a wide range of genetic and pathogenic diseases. Here, we discuss the recent breakthroughs in RNA engineering enabling these innovations and examine how advances in RNA design promise to accelerate the impact of engineered RNA systems.

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来源期刊
Annual review of chemical and biomolecular engineering
Annual review of chemical and biomolecular engineering CHEMISTRY, APPLIED-ENGINEERING, CHEMICAL
CiteScore
16.00
自引率
0.00%
发文量
25
期刊介绍: The Annual Review of Chemical and Biomolecular Engineering aims to provide a perspective on the broad field of chemical (and related) engineering. The journal draws from disciplines as diverse as biology, physics, and engineering, with development of chemical products and processes as the unifying theme.
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