Experimental Infection in Rabbits Evoked by Pseudomonas aeruginosa, Proteus mirabilis, Escherichia coli and Klebsiella pneumoniae Treated with Gentamicin, Amikacin and Sisomicin

Rabbits were infected with freshly isolated strains of Ps. aeruginosa, P. mirabilis, E. coli or K. pneumoniae and treated with gentamicin, amikacin or sisomicin in a controlled study. Therapeutic results were evaluated by survival of animals and viable counts of etiologic bacteria in several tissues after sacrification of treated animals at the same time. Sisomicin was the drug of choice for Ps. aeruginosa and P. mirabilis infections, when compared with amikacin and gentamicin. Its action is practically equal to that of amikacin in K. pneumoniae infection. Sisomicin appeared less active in E. coli infections than amikacin, but was superior to gentamicin.