{"title":"阿托品和柯碱对蛙缝匠肌终板电位时程的影响","authors":"M. Kordasˇ","doi":"10.1016/0028-3908(68)90064-6","DOIUrl":null,"url":null,"abstract":"<div><p>The effect of atropine and curarine on the time course of the end-plate potential was studied in the presence and absence of anticholinesterases.</p><p>Methods consisted of measuring the voltage-current relation of the muscle membrane, using microelectrophoretic application of acetylcholine to the end-plate region, and measuring end-plate current with a voltage-clamp technique.</p><p>Atropine (10<sup>−4</sup>Eq/1) decreased the amplitude and shortened the time course of the end-plate potential in curarized muscle. The underlying end-plate current was decreased on the average by about 20%, and its time course was shortened by 30–40%. These effects of atropine became more pronounced during treatment of the muscle with anticholinesterases prostigmine (3 × 10<sup>−6</sup>M), diisopropylfluorophosphate (10<sup>−4</sup> M) and tetraethylpyrophosphate (10<sup>−4</sup> M).</p><p>Curarine decreased the amplitude but did not affect the time course of the end-plate potential and end-plate current. During treatment of the muscle with prostigmine (3 × 10<sup>−6</sup>M) ,however, a similar increase in the concentration of curarine shortened the time course on the average by 5–10%.</p><p>It is possible that in presence of atropine and curarine a late component of transmitter action (e.g. on more distant receptors) is suppressed.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1968-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(68)90064-6","citationCount":"35","resultStr":"{\"title\":\"The effect of atropine and curarine on the time course of the end-plate potential in frog sartorius muscle\",\"authors\":\"M. Kordasˇ\",\"doi\":\"10.1016/0028-3908(68)90064-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The effect of atropine and curarine on the time course of the end-plate potential was studied in the presence and absence of anticholinesterases.</p><p>Methods consisted of measuring the voltage-current relation of the muscle membrane, using microelectrophoretic application of acetylcholine to the end-plate region, and measuring end-plate current with a voltage-clamp technique.</p><p>Atropine (10<sup>−4</sup>Eq/1) decreased the amplitude and shortened the time course of the end-plate potential in curarized muscle. The underlying end-plate current was decreased on the average by about 20%, and its time course was shortened by 30–40%. These effects of atropine became more pronounced during treatment of the muscle with anticholinesterases prostigmine (3 × 10<sup>−6</sup>M), diisopropylfluorophosphate (10<sup>−4</sup> M) and tetraethylpyrophosphate (10<sup>−4</sup> M).</p><p>Curarine decreased the amplitude but did not affect the time course of the end-plate potential and end-plate current. During treatment of the muscle with prostigmine (3 × 10<sup>−6</sup>M) ,however, a similar increase in the concentration of curarine shortened the time course on the average by 5–10%.</p><p>It is possible that in presence of atropine and curarine a late component of transmitter action (e.g. on more distant receptors) is suppressed.</p></div>\",\"PeriodicalId\":14111,\"journal\":{\"name\":\"International journal of neuropharmacology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1968-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0028-3908(68)90064-6\",\"citationCount\":\"35\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of neuropharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0028390868900646\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of neuropharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0028390868900646","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The effect of atropine and curarine on the time course of the end-plate potential in frog sartorius muscle
The effect of atropine and curarine on the time course of the end-plate potential was studied in the presence and absence of anticholinesterases.
Methods consisted of measuring the voltage-current relation of the muscle membrane, using microelectrophoretic application of acetylcholine to the end-plate region, and measuring end-plate current with a voltage-clamp technique.
Atropine (10−4Eq/1) decreased the amplitude and shortened the time course of the end-plate potential in curarized muscle. The underlying end-plate current was decreased on the average by about 20%, and its time course was shortened by 30–40%. These effects of atropine became more pronounced during treatment of the muscle with anticholinesterases prostigmine (3 × 10−6M), diisopropylfluorophosphate (10−4 M) and tetraethylpyrophosphate (10−4 M).
Curarine decreased the amplitude but did not affect the time course of the end-plate potential and end-plate current. During treatment of the muscle with prostigmine (3 × 10−6M) ,however, a similar increase in the concentration of curarine shortened the time course on the average by 5–10%.
It is possible that in presence of atropine and curarine a late component of transmitter action (e.g. on more distant receptors) is suppressed.
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