Maroua Slouma , Khaoula Ben Ali , Lobna Kharrat , Chadia Zouaoui , Haroun Ouertani , Imen Gharsallah
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We measured the following parameters: triglyceride (TG), high-density lipoproteins (HDL</span><sub>c</sub>), low-density lipoprotein cholesterol (LDL<sub>c</sub>), and total cholesterol (TC). We calculated TC/HDL<sub>c</sub>, TG/HDL<sub>c</sub>, LDL<sub>c</sub>/HDL<sub>c</sub> ratios, and atherogenic index of plasma (LogTG/HDL<sub>c</sub>).</p></div><div><h3>Results</h3><p>Metabolic syndrome was noted in 33% of cases. Patients with active disease had a higher body mass index (26.89<!--> <!-->±<!--> <!-->5.88 versus 23.63<!--> <!-->±<!--> <!-->4.47<!--> <!-->kg/m<sup>2</sup>, <em>p</em> <!-->=<!--> <span>0.03), higher TG (1.41</span> <!-->±<!--> <!-->0.64 versus 0.89<!--> <!-->±<!--> <!-->0.5<!--> <!-->mmol/L, <em>p</em> <!-->=<!--> <!-->0.05) and a lower HDL<sub>c</sub> level (1<!--> <!-->±<!--> <!-->0.28 versus 1.31<!--> <!-->±<!--> <!-->0.22<!--> <!-->mmol/L, <em>p</em> <!-->=<!--> <!-->0.01). However, the LogTG/HDL<sub>c</sub> and TG/HDL<sub>c</sub> were higher in patients under TNFα inhibitors. The ability of the TG/HDL<sub>c</sub> ratio and LogTG/HDL<sub>c</sub> to distinguish patients with or without metabolic syndrome were good at cut-offs of 1.33 and 0.22, respectively (specificity: 91.2% and sensitivity 70.6% for both ratios).</p></div><div><h3>Conclusion</h3><p>Our study showed that metabolic syndrome is frequent in patients with axial spondyloarthritis. Atherogenic indexes can be used for predicting metabolic syndrome in these patients.</p></div>","PeriodicalId":100263,"journal":{"name":"Clínica e Investigación en Arteriosclerosis (English Edition)","volume":"34 5","pages":"Pages 261-268"},"PeriodicalIF":0.0000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Athrogenic indexes: Useful markers for predicting metabolic syndrome in axial spondyloarthritis\",\"authors\":\"Maroua Slouma , Khaoula Ben Ali , Lobna Kharrat , Chadia Zouaoui , Haroun Ouertani , Imen Gharsallah\",\"doi\":\"10.1016/j.artere.2022.09.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>Metabolic syndrome is a pathological entity associated with a high risk of cardiovascular disease. Data regarding the frequency of this syndrome, lipid profile, and atherogenic index of plasma in patients with radiographic axial spondyloarthritis are scarce.</p><p>We aim to determine the prevalence of metabolic syndrome in patients with spondyloarthritis. We also aim to determine discriminative values of atherogenic indexes between patients with and without metabolic syndrome.</p></div><div><h3>Methods</h3><p><span>We conducted a cross-sectional study including 51 patients meeting the ASAS 2009 criteria for radiographic axial spondyloarthritis. We measured the following parameters: triglyceride (TG), high-density lipoproteins (HDL</span><sub>c</sub>), low-density lipoprotein cholesterol (LDL<sub>c</sub>), and total cholesterol (TC). We calculated TC/HDL<sub>c</sub>, TG/HDL<sub>c</sub>, LDL<sub>c</sub>/HDL<sub>c</sub> ratios, and atherogenic index of plasma (LogTG/HDL<sub>c</sub>).</p></div><div><h3>Results</h3><p>Metabolic syndrome was noted in 33% of cases. Patients with active disease had a higher body mass index (26.89<!--> <!-->±<!--> <!-->5.88 versus 23.63<!--> <!-->±<!--> <!-->4.47<!--> <!-->kg/m<sup>2</sup>, <em>p</em> <!-->=<!--> <span>0.03), higher TG (1.41</span> <!-->±<!--> <!-->0.64 versus 0.89<!--> <!-->±<!--> <!-->0.5<!--> <!-->mmol/L, <em>p</em> <!-->=<!--> <!-->0.05) and a lower HDL<sub>c</sub> level (1<!--> <!-->±<!--> <!-->0.28 versus 1.31<!--> <!-->±<!--> <!-->0.22<!--> <!-->mmol/L, <em>p</em> <!-->=<!--> <!-->0.01). However, the LogTG/HDL<sub>c</sub> and TG/HDL<sub>c</sub> were higher in patients under TNFα inhibitors. The ability of the TG/HDL<sub>c</sub> ratio and LogTG/HDL<sub>c</sub> to distinguish patients with or without metabolic syndrome were good at cut-offs of 1.33 and 0.22, respectively (specificity: 91.2% and sensitivity 70.6% for both ratios).</p></div><div><h3>Conclusion</h3><p>Our study showed that metabolic syndrome is frequent in patients with axial spondyloarthritis. Atherogenic indexes can be used for predicting metabolic syndrome in these patients.</p></div>\",\"PeriodicalId\":100263,\"journal\":{\"name\":\"Clínica e Investigación en Arteriosclerosis (English Edition)\",\"volume\":\"34 5\",\"pages\":\"Pages 261-268\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clínica e Investigación en Arteriosclerosis (English Edition)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2529912322000602\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clínica e Investigación en Arteriosclerosis (English Edition)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2529912322000602","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
代谢综合征是一种与心血管疾病高风险相关的病理实体。关于该综合征的发生频率、脂质谱和x线轴性脊柱炎患者血浆动脉粥样硬化指数的资料很少。我们的目的是确定代谢综合征在脊椎关节炎患者中的患病率。我们还旨在确定有代谢综合征和无代谢综合征患者的动脉粥样硬化指标的鉴别值。方法我们进行了一项横断面研究，包括51例符合ASAS 2009放射学标准的轴性脊柱炎患者。我们测量了以下参数:甘油三酯(TG)、高密度脂蛋白(HDLc)、低密度脂蛋白胆固醇(LDLc)和总胆固醇(TC)。我们计算了TC/HDLc、TG/HDLc、LDLc/HDLc比率和血浆的动脉粥样硬化指数(LogTG/HDLc)。结果33%的患者出现代谢综合征。活动期患者体质量指数较高(26.89±5.88比23.63±4.47 kg/m2, p = 0.03)， TG较高(1.41±0.64比0.89±0.5 mmol/L, p = 0.05)， HDLc水平较低(1±0.28比1.31±0.22 mmol/L, p = 0.01)。然而，TNFα抑制剂组患者的LogTG/HDLc和TG/HDLc较高。TG/HDLc比值和LogTG/HDLc区分有无代谢综合征的截断值分别为1.33和0.22(特异性为91.2%，敏感性为70.6%)。结论我们的研究表明，代谢综合征在轴型脊柱炎患者中是常见的。动脉粥样硬化指数可用于预测这些患者的代谢综合征。
Athrogenic indexes: Useful markers for predicting metabolic syndrome in axial spondyloarthritis
Introduction
Metabolic syndrome is a pathological entity associated with a high risk of cardiovascular disease. Data regarding the frequency of this syndrome, lipid profile, and atherogenic index of plasma in patients with radiographic axial spondyloarthritis are scarce.
We aim to determine the prevalence of metabolic syndrome in patients with spondyloarthritis. We also aim to determine discriminative values of atherogenic indexes between patients with and without metabolic syndrome.
Methods
We conducted a cross-sectional study including 51 patients meeting the ASAS 2009 criteria for radiographic axial spondyloarthritis. We measured the following parameters: triglyceride (TG), high-density lipoproteins (HDLc), low-density lipoprotein cholesterol (LDLc), and total cholesterol (TC). We calculated TC/HDLc, TG/HDLc, LDLc/HDLc ratios, and atherogenic index of plasma (LogTG/HDLc).
Results
Metabolic syndrome was noted in 33% of cases. Patients with active disease had a higher body mass index (26.89 ± 5.88 versus 23.63 ± 4.47 kg/m2, p = 0.03), higher TG (1.41 ± 0.64 versus 0.89 ± 0.5 mmol/L, p = 0.05) and a lower HDLc level (1 ± 0.28 versus 1.31 ± 0.22 mmol/L, p = 0.01). However, the LogTG/HDLc and TG/HDLc were higher in patients under TNFα inhibitors. The ability of the TG/HDLc ratio and LogTG/HDLc to distinguish patients with or without metabolic syndrome were good at cut-offs of 1.33 and 0.22, respectively (specificity: 91.2% and sensitivity 70.6% for both ratios).
Conclusion
Our study showed that metabolic syndrome is frequent in patients with axial spondyloarthritis. Atherogenic indexes can be used for predicting metabolic syndrome in these patients.
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