Keyvan Hejazi, Gholam Rasul Mohammad Rahimi, Sara K Rosenkranz
{"title":"运动训练对2型糖尿病患者炎症和心脏代谢风险生物标志物的影响:随机对照试验的系统回顾和荟萃分析","authors":"Keyvan Hejazi, Gholam Rasul Mohammad Rahimi, Sara K Rosenkranz","doi":"10.1177/10998004221132841","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The interaction between type 2 diabetes mellitus (T2DM) and cardiometabolic morbidity and mortality stems from the progressive nature of inflammation underpinning both diseases. Exercise training is considered an effective treatment strategy for T2DM and cardiometabolic diseases.</p><p><strong>Objective: </strong>The current systematic review and meta-analysis investigated the effects of exercise training on inflammatory and cardiometabolic risk biomarkers in patients with T2DM.</p><p><strong>Data sources: </strong>Electronic databases (PubMed/Medline, Embase, Cochrane Library, CINAHL, Google Scholar, Scopus, and Web of Science) were searched for randomized controlled trials (RCTs) from inception to January 2022. We used random effects models to estimate weighted mean differences with 95% confidence intervals.</p><p><strong>Study selection: </strong>Twenty-five RCTs were included (<i>N</i> = 1257 participants; mean age = 52 years). Included studies had moderate to good overall methodological quality (TESTEX = 9 (range 7-13).</p><p><strong>Results: </strong>Meta-analysis indicated that exercise training significantly increased adiponectin and decreased fasting insulin, homeostatic model assessment for insulin resistance, tumor necrosis factor-α, interleukin-6, and C-reactive protein (<i>p</i>s ≤ 0.05). Subgroup analysis by type of training indicated that aerobic exercise had the most consistent beneficial effects as compared to other types of exercise training; however, there was high heterogeneity among studies.</p><p><strong>Conclusion: </strong>Different types of exercise training increase adiponectin levels and decrease pro-inflammatory cytokines such as TNF-α, IL-6, and CRP, as well as fasting insulin and insulin resistance markers in patients with T2DM. However, these effects were not beneficial for more commonly measured cardiometabolic risk factors (i.e., lipid profiles). Additional relevant clinical trials are required to confirm these results.</p><p><strong>Trial registration: </strong>This systematic review and meta-analysis was prospectively registered in the PROSPERO database (CRD42022307396).</p>","PeriodicalId":8997,"journal":{"name":"Biological research for nursing","volume":"25 2","pages":"250-266"},"PeriodicalIF":1.9000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":"{\"title\":\"Effects of Exercise Training on Inflammatory and Cardiometabolic Risk Biomarkers in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.\",\"authors\":\"Keyvan Hejazi, Gholam Rasul Mohammad Rahimi, Sara K Rosenkranz\",\"doi\":\"10.1177/10998004221132841\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The interaction between type 2 diabetes mellitus (T2DM) and cardiometabolic morbidity and mortality stems from the progressive nature of inflammation underpinning both diseases. Exercise training is considered an effective treatment strategy for T2DM and cardiometabolic diseases.</p><p><strong>Objective: </strong>The current systematic review and meta-analysis investigated the effects of exercise training on inflammatory and cardiometabolic risk biomarkers in patients with T2DM.</p><p><strong>Data sources: </strong>Electronic databases (PubMed/Medline, Embase, Cochrane Library, CINAHL, Google Scholar, Scopus, and Web of Science) were searched for randomized controlled trials (RCTs) from inception to January 2022. We used random effects models to estimate weighted mean differences with 95% confidence intervals.</p><p><strong>Study selection: </strong>Twenty-five RCTs were included (<i>N</i> = 1257 participants; mean age = 52 years). Included studies had moderate to good overall methodological quality (TESTEX = 9 (range 7-13).</p><p><strong>Results: </strong>Meta-analysis indicated that exercise training significantly increased adiponectin and decreased fasting insulin, homeostatic model assessment for insulin resistance, tumor necrosis factor-α, interleukin-6, and C-reactive protein (<i>p</i>s ≤ 0.05). Subgroup analysis by type of training indicated that aerobic exercise had the most consistent beneficial effects as compared to other types of exercise training; however, there was high heterogeneity among studies.</p><p><strong>Conclusion: </strong>Different types of exercise training increase adiponectin levels and decrease pro-inflammatory cytokines such as TNF-α, IL-6, and CRP, as well as fasting insulin and insulin resistance markers in patients with T2DM. However, these effects were not beneficial for more commonly measured cardiometabolic risk factors (i.e., lipid profiles). Additional relevant clinical trials are required to confirm these results.</p><p><strong>Trial registration: </strong>This systematic review and meta-analysis was prospectively registered in the PROSPERO database (CRD42022307396).</p>\",\"PeriodicalId\":8997,\"journal\":{\"name\":\"Biological research for nursing\",\"volume\":\"25 2\",\"pages\":\"250-266\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2023-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biological research for nursing\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/10998004221132841\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NURSING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biological research for nursing","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/10998004221132841","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NURSING","Score":null,"Total":0}
引用次数: 6
摘要
背景:2型糖尿病(T2DM)与心脏代谢发病率和死亡率之间的相互作用源于两种疾病基础炎症的进行性。运动训练被认为是T2DM和心脏代谢疾病的有效治疗策略。目的:当前的系统回顾和荟萃分析调查了运动训练对T2DM患者炎症和心脏代谢风险生物标志物的影响。数据来源:检索电子数据库(PubMed/Medline, Embase, Cochrane Library, CINAHL, Google Scholar, Scopus和Web of Science)，检索随机对照试验(rct)，时间从初始到2022年1月。我们使用随机效应模型估计加权平均差异，置信区间为95%。研究选择:纳入25项随机对照试验(N = 1257名受试者;平均年龄= 52岁)。纳入的研究总体方法学质量中等至良好(TESTEX = 9(范围7-13))。结果:荟萃分析显示，运动训练显著增加脂联素，降低空腹胰岛素、胰岛素抵抗稳态模型评估、肿瘤坏死因子-α、白细胞介素-6和c反应蛋白(ps≤0.05)。按训练类型进行的亚组分析表明，与其他类型的运动训练相比，有氧运动具有最一致的有益效果;然而，研究之间存在高度异质性。结论:不同类型的运动训练可提高T2DM患者脂联素水平，降低促炎因子TNF-α、IL-6、CRP及空腹胰岛素和胰岛素抵抗指标。然而，这些影响对更常见的测量心脏代谢危险因素(即脂质谱)没有好处。需要更多的相关临床试验来证实这些结果。试验注册:该系统评价和荟萃分析在PROSPERO数据库(CRD42022307396)中前瞻性注册。
Effects of Exercise Training on Inflammatory and Cardiometabolic Risk Biomarkers in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Background: The interaction between type 2 diabetes mellitus (T2DM) and cardiometabolic morbidity and mortality stems from the progressive nature of inflammation underpinning both diseases. Exercise training is considered an effective treatment strategy for T2DM and cardiometabolic diseases.
Objective: The current systematic review and meta-analysis investigated the effects of exercise training on inflammatory and cardiometabolic risk biomarkers in patients with T2DM.
Data sources: Electronic databases (PubMed/Medline, Embase, Cochrane Library, CINAHL, Google Scholar, Scopus, and Web of Science) were searched for randomized controlled trials (RCTs) from inception to January 2022. We used random effects models to estimate weighted mean differences with 95% confidence intervals.
Study selection: Twenty-five RCTs were included (N = 1257 participants; mean age = 52 years). Included studies had moderate to good overall methodological quality (TESTEX = 9 (range 7-13).
Results: Meta-analysis indicated that exercise training significantly increased adiponectin and decreased fasting insulin, homeostatic model assessment for insulin resistance, tumor necrosis factor-α, interleukin-6, and C-reactive protein (ps ≤ 0.05). Subgroup analysis by type of training indicated that aerobic exercise had the most consistent beneficial effects as compared to other types of exercise training; however, there was high heterogeneity among studies.
Conclusion: Different types of exercise training increase adiponectin levels and decrease pro-inflammatory cytokines such as TNF-α, IL-6, and CRP, as well as fasting insulin and insulin resistance markers in patients with T2DM. However, these effects were not beneficial for more commonly measured cardiometabolic risk factors (i.e., lipid profiles). Additional relevant clinical trials are required to confirm these results.
Trial registration: This systematic review and meta-analysis was prospectively registered in the PROSPERO database (CRD42022307396).
期刊介绍：
Biological Research For Nursing (BRN) is a peer-reviewed quarterly journal that helps nurse researchers, educators, and practitioners integrate information from many basic disciplines; biology, physiology, chemistry, health policy, business, engineering, education, communication and the social sciences into nursing research, theory and clinical practice. This journal is a member of the Committee on Publication Ethics (COPE)
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
