Zn2+成像的最新进展:从细胞器到体内应用

IF 6.9 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current Opinion in Chemical Biology Pub Date : 2023-10-01 DOI:10.1016/j.cbpa.2023.102378

Hongbao Fang , Yaheng Li , Xiuzhi Yang , Yuncong Chen , Zijian Guo , Weijiang He

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引用次数: 0

摘要

Zn2+参与生命系统的各种生理和病理过程。监测Zn2+在细胞器、细胞和体内的动态时空变化，对研究Zn2+的生理和病理功能具有重要意义。然而，由于Zn2+在生命系统中的浓度很低且动态变化很快，因此这项任务具有相当大的挑战性。本文综述了近两年来报道的Zn2+荧光探针在细胞器、细胞和活生物体中的设计和应用。我们的目标是为设计用于多层次监测的新型Zn2+探针提供灵感，并加深对Zn2+生物学的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Recent advances in Zn2+ imaging: From organelles to in vivo applications

Zn²⁺ is involved in various physiological and pathological processes in living systems. Monitoring the dynamic spatiotemporal changes of Zn²⁺ levels in organelles, cells, and in vivo is of great importance for the investigation of the physiological and pathological functions of Zn²⁺. However, this task is quite challenging since Zn²⁺ in living systems is present at low concentrations and undergoes rapid dynamic changes. In this review, we summarize the design and application of fluorescent probes for Zn²⁺ imaging in organelles, cells, and live organisms reported over the past two years. We aim to provide inspiration for the design of novel Zn²⁺ probes for multi-level monitoring and deepen the understanding of Zn²⁺ biology.

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来源期刊

Current Opinion in Chemical Biology 生物-生化与分子生物学

CiteScore

13.30

自引率

1.30%

发文量

113

审稿时长

74 days

期刊介绍： COCHBI (Current Opinion in Chemical Biology) is a systematic review journal designed to offer specialists a unique and educational platform. Its goal is to help professionals stay informed about the growing volume of information in the field of Chemical Biology through systematic reviews.