Zn2+成像的最新进展:从细胞器到体内应用

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Nano Materials Pub Date : 2023-10-01 DOI:10.1016/j.cbpa.2023.102378

Hongbao Fang , Yaheng Li , Xiuzhi Yang , Yuncong Chen , Zijian Guo , Weijiang He

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引用次数: 0

摘要

Zn2+参与生命系统的各种生理和病理过程。监测Zn2+在细胞器、细胞和体内的动态时空变化，对研究Zn2+的生理和病理功能具有重要意义。然而，由于Zn2+在生命系统中的浓度很低且动态变化很快，因此这项任务具有相当大的挑战性。本文综述了近两年来报道的Zn2+荧光探针在细胞器、细胞和活生物体中的设计和应用。我们的目标是为设计用于多层次监测的新型Zn2+探针提供灵感，并加深对Zn2+生物学的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Recent advances in Zn2+ imaging: From organelles to in vivo applications

Zn²⁺ is involved in various physiological and pathological processes in living systems. Monitoring the dynamic spatiotemporal changes of Zn²⁺ levels in organelles, cells, and in vivo is of great importance for the investigation of the physiological and pathological functions of Zn²⁺. However, this task is quite challenging since Zn²⁺ in living systems is present at low concentrations and undergoes rapid dynamic changes. In this review, we summarize the design and application of fluorescent probes for Zn²⁺ imaging in organelles, cells, and live organisms reported over the past two years. We aim to provide inspiration for the design of novel Zn²⁺ probes for multi-level monitoring and deepen the understanding of Zn²⁺ biology.

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.