印度尼西亚痛风关节炎患者浸泡在20-30℃之间介导的炎症标志物中减轻疼痛:一项基于社区的随机对照试验

IF 1.9 4区医学 Q2 NURSING

Biological research for nursing Pub Date : 2023-04-01 DOI:10.1177/10998004221132843

Maria Dyah Kurniasari, Ferry Fredy Karwur, Rosiana Eva Rayanti, Ya Wen Shih, Sri Yuliana, Nae Fang Miao, Kuei Ru Chou, Chia Jung Shen, Hsiu Ting Tsai

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引用次数: 0

摘要

背景:痛风是由高尿酸水平引发的，并引起炎症、疼痛和生活质量受损。浸泡在20-30°C的水中可以减轻关节炎的炎症和疼痛。然而，20-30°C水中浸泡与尿酸水平和核苷酸结合结构域(NOD)样受体蛋白1 (NLRP1)炎性体之间的关系尚未明确。目的:我们旨在研究浸泡在20-30°C水中对急性痛风患者尿酸水平、NLRP1炎性体、疼痛和生活质量的影响。方法:采用基于社区的随机对照试验设计，分为2个平行干预组:20-30°C水浸泡组(20 min/d，持续4周)和对照组。印度尼西亚Tomohon市共有76名符合条件的参与者采用分组随机分配。我们分析结果(系数)。β)和95%置信区间(ci)使用广义估计方程模型。我们使用通径分析来分析中介效应。结果:显著缓解疼痛(β = -2.06 [95% CI = -2.67 ~ -1.45];β = -2.42 [95% CI = -2.97 ~ -1.87])和生活质量的改善(β = 5.34 [95% CI = 3.12 ~ 7.57];β = 9.93 [95% CI = 7.02-12.83])，在随访第2周和第4周时与前测组和对照组比较。在2周的随访中，尿酸水平(β = -0.34 [95% CI = -0.52 ~ -0.16])有所降低，但在20-30°C的水中浸泡后，NLRP1炎性体与测试前和对照组相比没有显著变化。NLRP1炎性小体(β = -0.48 [95% CI = -0.63 ~ -0.34]);水0.01)和尿酸水平(β = -0.11 [95% CI = -0.24 ~ -0.03];p < 0.01)对20-30°C浸泡水与4周随访疼痛之间的关系有部分间接(中介)影响。结论:浸泡在20-30°C的水中可显著减轻疼痛，提高生活质量。浸泡在20-30°C的水中可调节NLRP1和尿酸水平以减轻疼痛，但在随访4周后对NLRP1炎性体浓度没有显著影响，仅在浸泡在20-30°C的水中2周时才降低尿酸水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Immersion in Water Between 20-30^oC Mediated Inflammations Marker to Reduced Pain Among Indonesian With Gout Arthritis: A Community-Based Randomized Controlled Trial.

Background: Gout is triggered by high urate levels and causes inflammation, pain, and an impaired quality of life. Immersion in water at 20-30°C reduces inflammation and pain in arthritis. Yet, relationships of immersion in water at 20-30°C with urate levels and the nucleotide-binding domain (NOD)-like receptor protein 1 (NLRP1) inflammasome have never been clarified.

Objectives: We aimed to investigate the effects of immersion in water at 20-30°C on urate levels, the NLRP1 inflammasome, pain, and quality of life among acute gout patients.

Methods: A community-based randomized control trial design was used with 2 parallel-intervention groups: immersion in water at 20-30°C (20 min/day for 4 weeks) group and a control group. In total, 76 eligible participants in Tomohon City, Indonesia, were assigned using block randomization. We analyze the results (coef. β) and 95% confidence intervals (CIs) using a generalized estimating equation model. We analyzed mediating effects using a path analysis.

Results: Significant pain alleviation (β = -2.06 [95% CI = -2.67∼-1.45]; β = -2.42 [95% CI = -2.97∼-1.87]) and improved quality of life (β = 5.34 [95% CI = 3.12-7.57]; β = 9.93 [95% CI = 7.02-12.83]) were detected at 2 and 4 weeks of follow-up compared to the pre-test and control group. Urate levels (β = -0.34 [95% CI = -0.52∼-0.16]) were reduced at the 2-week follow-up, but there was no significant change in the NLRP1 inflammasome compared to the pre-test and control group after immersion in water at 20-30°C. Both the NLRP1 inflammasome (β = -0.48 [95% CI = -0.63∼-0.34]); water 0.01) and urate levels (β = -0.11 [95% CI = -0.24∼-0.03]; p < 0.01) had partial indirect (mediating) effects on the link between immersion in water at 20-30°C and pain at the 4-week follow-up.

Conclusions: Immersion in water at 20-30°C significantly decreased pain and increased the quality of life. Immersion in water at 20-30°C mediated NLRP1 and urate levels to decrease pain, although it had no significant effect on the NLRP1 inflammasome concentration after 4 weeks of follow-up and reduced urate levels only at 2 weeks after immersion in water at 20-30°C.

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来源期刊

Biological research for nursing 医学-护理

CiteScore

5.10

自引率

4.00%

发文量

审稿时长

>12 weeks

期刊介绍： Biological Research For Nursing (BRN) is a peer-reviewed quarterly journal that helps nurse researchers, educators, and practitioners integrate information from many basic disciplines; biology, physiology, chemistry, health policy, business, engineering, education, communication and the social sciences into nursing research, theory and clinical practice. This journal is a member of the Committee on Publication Ethics (COPE)