高水平的微卫星不稳定性和微卫星稳定性在DNA错配修复缺陷的结直肠癌患者中是相同的吗?

IF 2.7 4区 医学 Q2 Medicine
Yan-Yu Qiu, Yi-Xin Zeng, Yong Cheng
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引用次数: 0

摘要

目的:本研究的目的是确定DNA错配修复缺陷(DMMR)结直肠癌(CRC)患者中高水平的微卫星不稳定性(MSI-H)和微卫星稳定性(MSS)之间是否存在差异。方法:回顾性选择2014年12月至2021年4月在我院收治的452例大肠癌DMMR患者。然而,只有105名患者接受了Sanger或下一代测序(NGS)来确认他们的微卫星状态。最终,55例MSI-H患者和20例病历信息完整的MSS患者被纳入本研究。结果:MSS组KRAS基因突变率较高(P=0.011)。MSI-H与结肠癌相关(P < 0.01)。然而,两组患者在其他临床特征上无显著差异。MSI-H组与MSS组在总生存期(OS) (P=0.398)和无病生存期(DFS) (P=0.307)方面无显著差异。结论:DMMR患者MSI-H状态与结肠癌相关,KRAS基因突变率较低。在CRC-DMMR患者中,MSS组比MSI-H组表现出更好的OS和DFS,尽管这些差异无统计学意义。因此,在临床实践中,我们不应混淆这两类患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Are High Levels of Microsatellite Instability and Microsatellite Stability Identical in DNA Mismatch Repair-Deficient Colorectal Cancer Patients?

Are High Levels of Microsatellite Instability and Microsatellite Stability Identical in DNA Mismatch Repair-Deficient Colorectal Cancer Patients?

Are High Levels of Microsatellite Instability and Microsatellite Stability Identical in DNA Mismatch Repair-Deficient Colorectal Cancer Patients?

Purpose: The purpose of the current study was to determine whether there is a difference between high levels of microsatellite instability (MSI-H) and microsatellite stability (MSS) in DNA mismatch repair-deficient (DMMR) colorectal cancer (CRC) patients.

Methods: A total of 452 CRC patients with DMMR from December, 2014, to April, 2021, in our hospital were selected retrospectively. However, only 105 patients underwent Sanger or next-generation-sequencing (NGS) to confirm their microsatellite status. Ultimately, 55 MSI-H patients and 20 MSS patients with intact medical record information were included in this study.

Results: The MSS group was associated with a higher mutation rate in the KRAS gene (P=0.011). Meanwhile, MSI-H was related to colon cancer (P < 0.01). However, no significant differences in other clinical characteristics were observed between the two groups of patients. There was no significant difference between the MSI-H and MSS groups in terms of overall survival (OS) (P=0.398) and disease-free survival (DFS) (P=0.307).

Conclusion: The MSI-H status was associated with colon cancer and a lower mutation rate of the KRAS gene in DMMR patients. In CRC-DMMR patients, the MSS group exhibited better OS and DFS than the MSI-H group, although these differences were not statistically significant. Accordingly, in clinical practice, we should not confuse these two types of patients.

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来源期刊
CiteScore
4.80
自引率
0.00%
发文量
0
审稿时长
37 weeks
期刊介绍: Canadian Journal of Gastroenterology and Hepatology is a peer-reviewed, open access journal that publishes original research articles, review articles, and clinical studies in all areas of gastroenterology and liver disease - medicine and surgery. The Canadian Journal of Gastroenterology and Hepatology is sponsored by the Canadian Association of Gastroenterology and the Canadian Association for the Study of the Liver.
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