台式核磁共振光谱法同时测定多组分剂型:在苯妥英-苯巴比妥复方中的应用。

IF 1.8 4区医学 Q3 PHARMACOLOGY & PHARMACY

Iranian Journal of Pharmaceutical Research Pub Date : 2022-12-01 DOI:10.5812/ijpr-127040

Amin Nowroozi, Mohsen Shahlaei, Farzad Kobarfard

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引用次数: 0

摘要

使用核磁共振(NMR)光谱作为确定原料药及其剂型中的药物分子的工具正在增长。使用无低温磁体的台式核磁共振光谱仪的新进展使这项技术更具吸引力和可访问性。在此，我们开发了一种使用台式核磁共振光谱仪定量苯妥英(PhT)和苯巴比妥(PhB)散装和组合剂型的方法。结果与高效液相色谱法(HPLC)进行了比较。该方法操作简单，成本低，相对快速，优点值不逊于HPLC法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Simultaneous Determination of Multicomponent Dosage Forms Using Benchtop NMR Spectroscopy: Application to Phenytoin-Phenobarbital Combination.

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Simultaneous Determination of Multicomponent Dosage Forms Using Benchtop NMR Spectroscopy: Application to Phenytoin-Phenobarbital Combination.

The use of nuclear magnetic resonance (NMR) spectroscopy as a tool for determining pharmaceutical molecules in bulk drugs and their dosage forms is growing. New advancements in benchtop NMR spectrometers with cryogen-free magnets have made this technique more appealing and accessible. Herein, we developed a method using a benchtop NMR spectrometer to quantify phenytoin (PhT) and phenobarbital (PhB) in bulk and combined dosage forms. The results were compared to those obtained by high performance liquid chromatography (HPLC) as a well-characterized procedure. This method is simple, low cost, relatively fast, and non-inferior to HPLC in terms of figures of merit.

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来源期刊

Iranian Journal of Pharmaceutical Research 医学-药学

CiteScore

3.40

自引率

6.20%

发文量

审稿时长

2 months

期刊介绍： The Iranian Journal of Pharmaceutical Research (IJPR) is a peer-reviewed multi-disciplinary pharmaceutical publication, scheduled to appear quarterly and serve as a means for scientific information exchange in the international pharmaceutical forum. Specific scientific topics of interest to the journal include, but are not limited to: pharmaceutics, industrial pharmacy, pharmacognosy, toxicology, medicinal chemistry, novel analytical methods for drug characterization, computational and modeling approaches to drug design, bio-medical experience, clinical investigation, rational drug prescribing, pharmacoeconomics, biotechnology, nanotechnology, biopharmaceutics and physical pharmacy.