Yuedong Yang, Yongguo Zhou, W.-L Hou, Yongguang Zhao, Y. Ren
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Preparation and Anticoagulant Activity of Sulfated 6-Carboxychitosan
6-Carboxychitosan (6-CC), prepared by selectively oxidization of chitosan powder with NO2 gas in glacial acetic acid, was sulfated with chlorosulfoni acid in formamide to give sulfated 6-carboxylchitosan (S6CC). In S6CC, -SO3H groups were primarily grafted on -NH2, next on secondary -OH, and thirdly on -CH2OH positions. Sodium salt of S6CC (Na-S6CC) was more similar with heparin sodium than sulfated chitosan in both structure and anticoagulation activity.
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