石棉:纤维宽度在间皮瘤诱导中的作用。第一部分:芬兰石棉的流行病学研究

E. Ilgren, J. Hoskins
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引用次数: 2

摘要

anthophylite石棉只在世界上少数几个地方有足够的开采量。最大的花青石石棉矿床位于芬兰,在那里它被开采了75年以上,并且在古代被广泛使用和分布了6000多年。花青石是五种矿物之一,统称为角闪孔石棉。对吸入这五种矿物纤维的影响的研究表明,纤维宽度是诱导间皮瘤的重要决定因素。只有“较薄”的纤维或那些纤维直径尺寸轮廓主要小于0.25 - 0.30µm的纤维才明显是间皮瘤。“较厚”的或那些主要宽度大于这些直径的似乎没有显示出可观察到的间皮瘤伴随风险。基于对至少两种“厚”形式的角闪孔石棉的研究的观察支持了这些假设。一个是玻利维亚的鳄鱼石;另一种芬兰花青石。芬兰的花青石行业提供了一个重要的机会来研究纤维宽度是间皮瘤发生的关键这一理论的稳健性,因为在芬兰工业的所有部门中,大量的人及其家庭在历史上遭受了大量的纤维暴露,足以导致石棉肺的严重过剩。然而,尽管存在这些长期、高剂量的暴露,仍然缺乏明确的证据表明花石石棉有间皮瘤风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anthophyllite Asbestos: The Role of Fiber Width in Mesothelioma Induction Part 1: Epidemiological Studies of Finnish Anthophyllite Asbestos
Anthophyllite asbestos only occurs in a few parts of the world in sufficient quantities to be mined. The largest deposits of anthophyllite asbestos occur in Finland where it was mined for more than 75 years and very extensively used and distributed, anciently, for more than six millennia. Anthophyllite is one of the five minerals known collectively as amphibole asbestos. Studies of the effect of these five mineral fibre types when inhaled have shown that fibre width is an important determinant of mesothelioma induction. Only the “thinner” fibres or those with fiber diameter dimensional profiles predominantly less than 0.25 – 0.30 µm, are clearly mesotheliogenic. The “thicker” ones or those whose predominant widths are greater than these diameters do not appear to show an observable attendant risk of mesothelioma. Observations based on studies of at least, two “thick” forms of amphibole asbestos support these hypotheses. The one is Bolivian crocidolite; the other Finnish anthophyllite. The Finnish anthophyllite industry presents an important opportunity to study the robustness of the theory that fibre width is key to mesothelioma genesis as vast numbers of people in all sectors of the Finnish industry and their families have historically incurred massive fiber exposures sufficient to cause a gross excess of asbestosis. Nonetheless, in spite of these long term, high dose exposures clear evidence for a mesothelioma risk due to anthophyllite asbestos is still lacking.
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