PROMIS PF-10在炎症性风湿病和身体功能严重受限患者中的构建效度

IF 2.2 4区医学 Q3 RHEUMATOLOGY

Scandinavian Journal of Rheumatology Pub Date : 2023-11-01 Epub Date: 2023-03-20 DOI:10.1080/03009742.2023.2182449

Mat van Wissen, B Straathof, Tpm Vliet Vlieland, Chm van den Ende, Mmh Teuwen, W F Peter, A A den Broeder, W B van den Hout, D van Schaardenburg, A M van Tubergen, Mgj Gademan, Sfe van Weely

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引用次数: 0

摘要

目的:评估患者报告结果测量信息系统身体功能10项短表(PROMIS PF-10)在严重身体功能受限(PF)的类风湿关节炎(RA)或轴性脊柱炎(axSpA)患者亚群中的结构效度。方法:严重功能限制的RA/axSpA患者完成PROMIS PF-10、健康评估问卷-残疾指数(RA为HAQ-DI)或Bath强直性脊柱炎功能指数(axSpA为BASFI)、36项简短健康调查(SF-36)、EuroQol 5维5级(指数评分，EQ-VAS)，并进行6分钟步行测试(6MWT)。通过计算Spearman秩或Pearson相关系数和检验PROMIS PF-10与PF测量和生活质量之间相关性的假设来评估结构效度。结果:316例患者(180 RA/136 axSpA, 91.7%/47.8%为女性，平均±sd年龄58.6±13.2/54.0±11.3岁)。RA患者的中位(IQR) PROMIS PF-10评分为34.5 (31.4-37.6)，axSpA患者为36.0(32.8-38.3)。PROMIS PF-10与HAQ-DI、BASFI和EQ-5D-5L指数评分呈强相关(r < 0 0.6)，与SF-36身体成分综合评分、EQ-VAS和6MWT呈正相关(0.30≤r≤0.60)，与SF-36心理成分综合评分呈弱相关(r < 0 0.6)。在具有严重功能限制的RA和axSpA患者亚群中，PROMIS PF-10与PF测量值的总体强相关性和与测量不同结构的结果的中度至弱相关性得到证实，支持其结构效度。

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Construct validity of the PROMIS PF-10 in patients with inflammatory rheumatic diseases and severe limitations in physical functioning.

Objective: Assessing the construct validity of the Patient-Reported Outcomes Measurement Information System Physical Function 10-Item Short Form (PROMIS PF-10) in a subpopulation of rheumatoid arthritis (RA) or axial spondyloarthritis (axSpA) patients with severe limitations in physical functioning (PF).

Method: RA/axSpA patients with severe functional limitations completed the PROMIS PF-10, Health Assessment Questionnaire - Disability Index (HAQ-DI for RA) or Bath Ankylosing Spondylitis Functional Index (BASFI for axSpA), 36-item Short Form Health Survey (SF-36), EuroQol 5-dimensions 5-level (index score, EQ-VAS), and performed the Six-Minute Walk Test (6MWT). Construct validity was assessed by computing Spearman rank or Pearson correlation coefficients and testing hypotheses about correlations between the PROMIS PF-10 and measures of PF and quality of life.

Results: Data from 316 patients (180 RA/136 axSpA, 91.7%/47.8% female, mean ± sd age 58.6 ± 13.2/54.0 ± 11.3 years) were analysed. The median (IQR) PROMIS PF-10 score was 34.5 (31.4-37.6) in RA and 36.0 (32.8-38.3) in axSpA patients. The PROMIS PF-10 correlated strongly with the HAQ-DI, BASFI, and EQ-5D-5L index score (r > 0.6), moderately with the SF-36 Physical Component Summary score, EQ-VAS, and 6MWT (0.30 ≤ r ≤ 0.60), and weakly with the SF-36 Mental Component Summary score (r < 0.30). Five of six hypotheses (83%) were confirmed in both groups.

Conclusion: The overall strong correlation of the PROMIS PF-10 with measures of PF and moderate to weak correlations with outcomes measuring different constructs were confirmed in subpopulations of RA and axSpA patients with severe functional limitations, supporting its construct validity.

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来源期刊

Scandinavian Journal of Rheumatology 医学-风湿病学

CiteScore

3.70

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Scandinavian Journal of Rheumatology is the official journal of the Scandinavian Society for Rheumatology, a non-profit organization following the statutes of the Scandinavian Society for Rheumatology/Scandinavian Research Foundation. The main objective of the Foundation is to support research and promote information and knowledge about rheumatology and related fields. The annual surplus by running the Journal is awarded to young, talented, researchers within the field of rheumatology.pasting The Scandinavian Journal of Rheumatology is an international scientific journal covering clinical and experimental aspects of rheumatic diseases. The journal provides essential reading for rheumatologists as well as general practitioners, orthopaedic surgeons, radiologists, pharmacologists, pathologists and other health professionals with an interest in patients with rheumatic diseases. The journal publishes original articles as well as reviews, editorials, letters and supplements within the various fields of clinical and experimental rheumatology, including; Epidemiology Aetiology and pathogenesis Treatment and prophylaxis Laboratory aspects including genetics, biochemistry, immunology, immunopathology, microbiology, histopathology, pathophysiology and pharmacology Radiological aspects including X-ray, ultrasonography, CT, MRI and other forms of imaging.