Barbara Prack McCormick , María P. Quiroga , Verónica E. Álvarez , Daniela Centrón , Pablo Tittonell
{"title":"阿根廷与集约化畜牧生产实践相关的抗菌素耐药性传播:系统回顾和荟萃分析","authors":"Barbara Prack McCormick , María P. Quiroga , Verónica E. Álvarez , Daniela Centrón , Pablo Tittonell","doi":"10.1016/j.ram.2022.07.001","DOIUrl":null,"url":null,"abstract":"<div><p>Abuse and misuse of antimicrobial agents has accelerated the spread of antimicrobial-resistant bacteria. The association between antimicrobial-resistant infections in humans and antimicrobial use in agriculture is complex, but well-documented. This study provides a systematic review and meta-analysis of the dissemination of antimicrobial resistance (AMR) to antimicrobials defined as critically important by the WHO, in swine, chicken, and cattle from intensive and extensive production systems in Argentina. We conducted searches in electronic databases (MEDLINE-PubMed, Web of Science, SciELO, the National System of Digital Repositories from Argentina) as well as in the gray literature. Inclusion criteria were epidemiological studies on AMR in the main food-transmitted bacteria, <em>Salmonella</em> spp., <em>Campylobacter</em> spp., <em>Escherichia coli</em> and <em>Enterococcus</em> spp., and mastitis-causing bacteria, isolated from swine, chicken, dairy and beef cattle from Argentina. This study gives evidence for supporting the hypothesis that AMR of common food-transmitted bacteria in Argentina is reaching alarming levels. Meta-analyses followed by subgroup analyses confirmed the association between the prevalence of AMR and (a) animal species (<em>p</em> <!--><<!--> <!-->0.01) for streptomycin, ampicillin and tetracycline or (b) the animal production system (<em>p</em> <!--><<!--> <!-->0.05) for streptomycin, cefotaxime, nalidixic acid, ampicillin and tetracycline. Moreover, swine (0.47 [0.29; 0.66]) and intensive production (0.62 [0.34; 0.83]) showed the highest pooled prevalence of multidrug resistance while dairy (0.056 [0.003; 0.524]) and extensive production (0.107 [0.043; 0.240]) showed the lowest. A research gap regarding beef-cattle from feedlot was identified. Finally, there is an urgent need for political measures meant to coordinate and harmonize AMR surveillance and regulate antimicrobial use in animal production.</p></div>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Antimicrobial resistance dissemination associated with intensive animal production practices in Argentina: A systematic review and meta-analysis\",\"authors\":\"Barbara Prack McCormick , María P. Quiroga , Verónica E. Álvarez , Daniela Centrón , Pablo Tittonell\",\"doi\":\"10.1016/j.ram.2022.07.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Abuse and misuse of antimicrobial agents has accelerated the spread of antimicrobial-resistant bacteria. The association between antimicrobial-resistant infections in humans and antimicrobial use in agriculture is complex, but well-documented. This study provides a systematic review and meta-analysis of the dissemination of antimicrobial resistance (AMR) to antimicrobials defined as critically important by the WHO, in swine, chicken, and cattle from intensive and extensive production systems in Argentina. We conducted searches in electronic databases (MEDLINE-PubMed, Web of Science, SciELO, the National System of Digital Repositories from Argentina) as well as in the gray literature. Inclusion criteria were epidemiological studies on AMR in the main food-transmitted bacteria, <em>Salmonella</em> spp., <em>Campylobacter</em> spp., <em>Escherichia coli</em> and <em>Enterococcus</em> spp., and mastitis-causing bacteria, isolated from swine, chicken, dairy and beef cattle from Argentina. This study gives evidence for supporting the hypothesis that AMR of common food-transmitted bacteria in Argentina is reaching alarming levels. Meta-analyses followed by subgroup analyses confirmed the association between the prevalence of AMR and (a) animal species (<em>p</em> <!--><<!--> <!-->0.01) for streptomycin, ampicillin and tetracycline or (b) the animal production system (<em>p</em> <!--><<!--> <!-->0.05) for streptomycin, cefotaxime, nalidixic acid, ampicillin and tetracycline. Moreover, swine (0.47 [0.29; 0.66]) and intensive production (0.62 [0.34; 0.83]) showed the highest pooled prevalence of multidrug resistance while dairy (0.056 [0.003; 0.524]) and extensive production (0.107 [0.043; 0.240]) showed the lowest. A research gap regarding beef-cattle from feedlot was identified. Finally, there is an urgent need for political measures meant to coordinate and harmonize AMR surveillance and regulate antimicrobial use in animal production.</p></div>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S032575412200058X\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S032575412200058X","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 4
摘要
滥用和滥用抗微生物剂加速了抗微生物细菌的传播。人类抗微生物感染与农业中使用抗微生物药物之间的关系很复杂,但有充分的证据。本研究对世界卫生组织定义为至关重要的抗生素在阿根廷密集和广泛生产系统的猪、鸡和牛中的耐药性(AMR)传播情况进行了系统回顾和荟萃分析。我们在电子数据库(MEDLINE PubMed、Web of Science、SciELO、阿根廷国家数字存储库系统)以及灰色文献中进行了搜索。纳入标准是对从阿根廷猪、鸡、奶制品和肉牛中分离的主要食物传播细菌沙门氏菌、弯曲杆菌、大肠杆菌和肠球菌以及引起乳腺炎的细菌中AMR的流行病学研究。这项研究为支持阿根廷常见食物传播细菌的AMR达到惊人水平的假设提供了证据。Meta分析和亚组分析证实了AMR的患病率与(a)链霉素、氨苄青霉素和四环素的动物种类(p<0.01)或(b)链霉素,头孢噻肟,萘啶酸,氨苄青霉素及四环素的动物生产系统(p<0.05)之间的关联。此外,猪(0.47[0.29;0.66])和集约生产(0.62[0.34;0.83])显示出最高的多药耐药性综合患病率,而乳制品(0.056[0.03;0.524])和粗放生产(0.107[0.043;0.240])显示出最低的多药耐药综合患病率。发现了饲养场肉牛的研究空白。最后,迫切需要采取旨在协调和统一AMR监测和监管动物生产中抗菌药物使用的政治措施。
Antimicrobial resistance dissemination associated with intensive animal production practices in Argentina: A systematic review and meta-analysis
Abuse and misuse of antimicrobial agents has accelerated the spread of antimicrobial-resistant bacteria. The association between antimicrobial-resistant infections in humans and antimicrobial use in agriculture is complex, but well-documented. This study provides a systematic review and meta-analysis of the dissemination of antimicrobial resistance (AMR) to antimicrobials defined as critically important by the WHO, in swine, chicken, and cattle from intensive and extensive production systems in Argentina. We conducted searches in electronic databases (MEDLINE-PubMed, Web of Science, SciELO, the National System of Digital Repositories from Argentina) as well as in the gray literature. Inclusion criteria were epidemiological studies on AMR in the main food-transmitted bacteria, Salmonella spp., Campylobacter spp., Escherichia coli and Enterococcus spp., and mastitis-causing bacteria, isolated from swine, chicken, dairy and beef cattle from Argentina. This study gives evidence for supporting the hypothesis that AMR of common food-transmitted bacteria in Argentina is reaching alarming levels. Meta-analyses followed by subgroup analyses confirmed the association between the prevalence of AMR and (a) animal species (p < 0.01) for streptomycin, ampicillin and tetracycline or (b) the animal production system (p < 0.05) for streptomycin, cefotaxime, nalidixic acid, ampicillin and tetracycline. Moreover, swine (0.47 [0.29; 0.66]) and intensive production (0.62 [0.34; 0.83]) showed the highest pooled prevalence of multidrug resistance while dairy (0.056 [0.003; 0.524]) and extensive production (0.107 [0.043; 0.240]) showed the lowest. A research gap regarding beef-cattle from feedlot was identified. Finally, there is an urgent need for political measures meant to coordinate and harmonize AMR surveillance and regulate antimicrobial use in animal production.
期刊介绍:
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.