[植物源性功能性食品成分中多糖与微量生物活性化合物的相互作用评价]。

Q2 Medicine
D O Bokov, M N Bogachuk, A D Malinkin, V A Nazarova, V V Bessonov
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引用次数: 0

摘要

目前,以植物源性生物活性化合物(BAC)为基础创造丰富化、专门化、功能化产品的科学观点已经形成。多糖(水胶体)、食物系统中的宏量营养素和微量BAC之间的相互作用是其生物利用度的决定性因素,在开发配方并进行相应评估时应考虑到这一点。本研究的目的是考虑植物源性功能性食品成分中多糖和微量BAC相互作用的理论方面,并概述目前可用的评估方法。材料和方法。论文的检索和分析主要使用了eLIBRARY, PubMed, Scopus, Web of Science数据库,主要是近10年的。结果。以多酚复合物(黄酮类化合物)、表皮甾体为例,确定了多糖与微量BAC的主要相互作用机制。这些包括:吸附,“包合物”的形成,羟基之间的氢键。BAC与其他大分子的相互作用可以发生,并且由于形成络合物而使其发生显着改变,并导致生物活性降低。水胶体与少量BAC的相互作用程度的评估可以通过体外和体内两种方法进行。这些研究大多是在体外进行的,没有考虑到影响BAC生物利用度的许多因素。因此,值得注意的是,尽管基于药用植物的功能性食品成分的开发取得了重大进展,但目前使用相关模型研究BAC与多糖相互作用的研究还没有达到必要的程度。结论。综上所述,植物多糖(水胶体)对少量BAC(多酚、外甾体)的生物活性和可利用性有显著影响。作为初步评估相互作用程度的最佳技术,建议使用包括主要酶系统的模型,这样可以准确地重现胃肠道中发生的过程;在最后阶段,需要在体内确认生物活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Interaction assessment of polysaccharides and minor bioactive compounds in functional food ingredients of plant origin].

At present, the scientific based view of creation enriched, specialized and functional products based on bioactive compounds (BAC) of plant origin has been formed. Interactions between polysaccharides (hydrocolloids), macronutrients of the food system and minor BAC are a determining factor in their bioavailability and should be taken into account when developing formulations and evaluated accordingly. The objective of the research was to consider the theoretical aspects of the interaction of polysaccharides and minor BAC in functional food ingredients of plant origin, as well as to provide an overview of currently available methods for their evaluation. Material and methods. The search and analysis of publications were carried out using the eLIBRARY, PubMed, Scopus, Web of Science databases, mainly in the last 10 years. Results. The main interaction mechanisms of the polysaccharides with minor BAC were determined using the example of the components of the polyphenol complex (flavonoids), ecdysteroids. These include: adsorption, the formation of an "inclusion complex", hydrogen bonding between OH-groups. The interaction of BAC with other macromolecules can occur with their significant modification as a result of the formation of complexes and cause a decrease in biological activity. The assessment of the degree of interaction of hydrocolloids with minor BAC can be carried out using both in vitro and in vivo methods. Most of these studies are carried out in vitro, do not take into account many factors that affect the bioavailability of BAC. Thus, it can be noted that, despite significant progress in the development of functional food ingredients based on medicinal plant materials, the studies of the interactions of BAC with polysaccharides using relevant models are not currently carried out to the extent necessary. Conclusion. Based on the data presented in the review, it can be concluded that plant polysaccharides (hydrocolloids) have a significant effect on the biological activity and availability of minor BAC (polyphenols, ecdysteroids). As an optimal technique for a preliminary assessment of the degree of interaction, it is recommended to use a model that includes the main enzymatic systems, which allows you to accurately reproduce the processes occurring in the gastrointestinal tract; at the final stage, it is necessary to confirm the biological activity in vivo.

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Voprosy pitaniia
Voprosy pitaniia Medicine-Medicine (all)
CiteScore
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