年龄相关围手术期神经认知障碍:实验模型和药物靶点。

IF 11.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Odmara L Barreto Chang, Katherine L Possin, Mervyn Maze
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引用次数: 6

摘要

随着世界范围内寿命的增加,手术患者年龄越来越大,术后认知障碍的倾向也越来越大,要么是新发的,要么是由于现有疾病的恶化;在这两种情况下,了解患者的术前认知功能和术后认知轨迹是必要的。我们描述了一种基于平板电脑的快速评估执行功能所需的记忆和注意力域的临床应用。围手术期神经认知障碍的致病机制已经在动物模型中进行了研究,其中过度和/或长期的术后神经炎症已成为可能的竞争者。参与术后神经炎症的细胞和分子物种是未来有效且不干扰手术患者愈合过程的治疗干预的假定目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Age-Related Perioperative Neurocognitive Disorders: Experimental Models and Druggable Targets.

With the worldwide increase in life span, surgical patients are becoming older and have a greater propensity for postoperative cognitive impairment, either new onset or through deterioration of an existing condition; in both conditions, knowledge of the patient's preoperative cognitive function and postoperative cognitive trajectory is imperative. We describe the clinical utility of a tablet-based technique for rapid assessment of the memory and attentiveness domains required for executive function. The pathogenic mechanisms for perioperative neurocognitive disorders have been investigated in animal models in which excessive and/or prolonged postoperative neuroinflammation has emerged as a likely contender. The cellular and molecular species involved in postoperative neuroinflammation are the putative targets for future therapeutic interventions that are efficacious and do not interfere with the surgical patient's healing process.

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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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