人类唾液干/祖细胞微观结构动态组装的物理模型

IF 3.9 4区生物学 Q4 Biochemistry, Genetics and Molecular Biology

Cells and Development Pub Date : 2022-09-01 DOI:10.1016/j.cdev.2022.203803

Yuyang Chen , Danielle Wu , Herbert Levine

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引用次数: 1

摘要

在体外重建人类唾液腺服务于其最终的医疗用途代表了组织工程的挑战。在这里，我们提出了一种理论方法来研究人类唾液细胞的腺泡结构的动态形成，重点关注观察到的粘滑径向扩张以及可能的生长不稳定性。我们的研究结果表明，基底膜重塑在控制生长过程中至关重要。

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A physical model for dynamic assembly of human salivary stem/progenitor microstructures

The in vitro reconstructions of human salivary glands in service of their eventual medical use represent a challenge for tissue engineering. Here, we present a theoretical approach to the dynamical formation of acinar structures from human salivary cells, focusing on observed stick-slip radial expansion as well as possible growth instabilities. Our findings demonstrate the critical importance of basement membrane remodeling in controlling the growth process.

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来源期刊

Cells and Development Biochemistry, Genetics and Molecular Biology-Developmental Biology

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

41 days