气道微生物组- il -17轴:慢性炎性疾病的关键调节因子。

IF 8.4 2区 医学 Q1 ALLERGY
Jenny M Mannion, Rachel M McLoughlin, Stephen J Lalor
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引用次数: 8

摘要

呼吸道是多种微生物群落的家园,它们对局部和全身免疫反应的影响才刚刚开始受到重视。越来越多的报告将这种微生物群的变化与一系列肺部和肺外疾病联系起来,包括哮喘、慢性阻塞性肺病和类风湿性关节炎。许多这些发现的核心是il -17型免疫作为炎症的重要驱动因素的作用。尽管il -17介导的免疫应答在抗感染保护中起着至关重要的作用,但明显的Th17细胞应答与几种慢性炎症性疾病的发病机制有关。然而,我们对通常在呼吸道定植的细菌对il -17驱动的炎症反应的影响的了解仍然很少。在这篇文章中,我们回顾了目前关于气道微生物群特定成员在调节il -17型免疫中的作用的知识,并讨论了这条研究路线如何支持易感个体的检测和早期炎症的靶向,以期预防慢性疾病的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Airway Microbiome-IL-17 Axis: a Critical Regulator of Chronic Inflammatory Disease.

The Airway Microbiome-IL-17 Axis: a Critical Regulator of Chronic Inflammatory Disease.

The Airway Microbiome-IL-17 Axis: a Critical Regulator of Chronic Inflammatory Disease.

The Airway Microbiome-IL-17 Axis: a Critical Regulator of Chronic Inflammatory Disease.

The respiratory tract is home to a diverse microbial community whose influence on local and systemic immune responses is only beginning to be appreciated. Increasing reports have linked changes in this microbiome to a range of pulmonary and extrapulmonary disorders, including asthma, chronic obstructive pulmonary disease and rheumatoid arthritis. Central to many of these findings is the role of IL-17-type immunity as an important driver of inflammation. Despite the crucial role played by IL-17-mediated immune responses in protection against infection, overt Th17 cell responses have been implicated in the pathogenesis of several chronic inflammatory diseases. However, our knowledge of the influence of bacteria that commonly colonise the respiratory tract on IL-17-driven inflammatory responses remains sparse. In this article, we review the current knowledge on the role of specific members of the airway microbiota in the modulation of IL-17-type immunity and discuss how this line of research may support the testing of susceptible individuals and targeting of inflammation at its earliest stages in the hope of preventing the development of chronic disease.

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来源期刊
CiteScore
22.30
自引率
1.10%
发文量
58
审稿时长
6-12 weeks
期刊介绍: Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.
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