肽去甲酰基酶抑制剂解决细菌耐药性问题

International Review of Biophysical Chemistry Pub Date : 2013-02-28 DOI:10.15866/IREBIC.V4I1.1582

T. Kumari, R. Arora, R. Kakkar

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引用次数: 1

摘要

肽脱甲酰基酶(Peptide Deformylase, PDF)是一种很有吸引力的抗菌靶点，由于其显著的特性，在当代研究中获得了很大的发展势头。本文综述了细菌PDF结构和设计新型PDF抑制剂所需的标准。它也提出了一个总结的已知和最近探索类PDF抑制剂，肽类和非肽类

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Peptide Deformylase Inhibitors for Addressing the Issue of Bacterial Resistance

Peptide Deformylase (PDF) is an attractive antibacterial target, and is gaining much momentum in contemporary research because of its remarkable features. This article reviews the bacterial PDF structure and criteria required for designing novel PDF inhibitors. It also presents a summary of the known and recently explored classes of PDF inhibitors, both peptidic and non-peptidic

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International Review of Biophysical Chemistry

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