Mumefural通过改善2型糖尿病间质液pH值降低,防止胰岛素抵抗和β淀粉样蛋白在脑内积聚。

IF 1.3 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Shigekuni Hosogi, Atsukazu Kuwahara, Yuko Kuwahara, Saori Tanaka, Chikao Shimamoto, Noriko Tagawa, Ikuo Kato, Kanji Yoshimoto, Wataru Aoi, Kazuyuki Takata, Hiroaki Miyazaki, Naomi Niisato, Yasuhiro Tsubo, Katsumi Yagi, Takashi Nakahari, Yoshinori Marunaka
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引用次数: 3

摘要

本研究试图澄清momural是否可以预防高血糖,高血糖是2型糖尿病(T2DM)的典型症状之一,因为momural是从日本杏中提取的一种预防高血糖的提取物。为了明确纪念馆是否可以预防T2DM的发病机制,我们使用大冢Long-Evans德岛脂肪(OLETF)大鼠,T2DM模型。空腹条件下OLETF大鼠的高血糖、HOMA-IR和血浆甘油三酯浓度均有明显降低。此外,粘膜升高了远端结肠钠偶联单羧酸转运蛋白1 (SMCT1)的蛋白表达,参与弱有机酸的吸收,弱有机酸在吸收进入体内后表现为碱而不是酸。与作为OLETF大鼠对照的非t2dm LETO大鼠相比,纪念馆还增加了OLETF大鼠脑海马周围的间质液pH值。脑内淀粉样蛋白积累随pH值升高而减少。一方面,在空腹条件下,纪念碑不影响血浆胰高血糖素、GLP-1、GIP和PYY的浓度。综上所述,这些观察结果表明:1)乳糜泻可能是改善T2DM患者高血糖、胰岛素抵抗和降低间质液pH值的有用功能性食品;2)间质液pH值可能是影响淀粉样蛋白积累的关键因素之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mumefural prevents insulin resistance and amyloid-beta accumulation in the brain by improving lowered interstitial fluid pH in type 2 diabetes mellitus.

The present study tried to clarify if mumefural would prevent hyperglycemia, one of the typical symptoms of type 2 diabetes mellitus (T2DM), since mumefural is an extract from Japanese apricots preventing hyperglycemia. To clarify if mumefural would prevent T2DM pathogenesis, we used Otsuka Long-Evans Tokushima fatty (OLETF) rats, T2DM model. Mumefural diminished hyperglycemia, HOMA-IR and plasma triglyceride concentration in OLETF rats under fasting conditions. In addition, mumefural elevated protein expression of sodium-coupled monocarboxylate transporter 1 (SMCT1) in the distal colon participating in absorption of weak organic acids, which behave as bases but not acids after absorption into the body. Mumefural also increased the interstitial fluid pH around the brain hippocampus lowered in OLETF rats compared with non-T2DM LETO rats used as control for OLETF rats. Amyloid-beta accumulation in the brain decreased in accordance with the pH elevation. On the one hand, mumefural didn't affect plasma concentrations of glucagon, GLP-1, GIP or PYY under fasting conditions. Taken together, these observations indicate that: 1) mumefural would be a useful functional food improving hyperglycemia, insulin resistance and the lowered interstitial fluid pH in T2DM; 2) the interstitial fluid pH would be one of key factors influencing the accumulation of amyloid-beta.

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来源期刊
Biomedical Research-tokyo
Biomedical Research-tokyo 医学-医学:研究与实验
CiteScore
2.40
自引率
0.00%
发文量
19
审稿时长
>12 weeks
期刊介绍: Biomedical Research is peer-reviewed International Research Journal . It was first launched in 1990 as a biannual English Journal and later became triannual. From 2008 it is published in Jan-Apr/ May-Aug/ Sep-Dec..
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