神经性疼痛:机理、性别差异和解决全球性问题的潜在疗法。

IF 11.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Shahrzad Ghazisaeidi, Milind M Muley, Michael W Salter
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引用次数: 20

摘要

有关慢性疼痛的研究发表了越来越多的论文,但安全有效的慢性疼痛治疗方法仍然难以找到。由于人们认识到慢性疼痛的性别特异性机制,因此包括男女两性在内的研究激增。研究的主要重点是确定性别差异,然而许多新发现的细胞机制和基因表达的改变在两性之间是一致的。在此,我们回顾了驱动神经病理性疼痛产生和缓解的细胞和分子信号的性别差异和相似性。这些异同反映了神经元、免疫细胞和神经胶质细胞共同驱动痛觉过敏的外周和中枢信号过程的退化。最近发现的关键信号节点预示着合理设计、广泛适用的镇痛策略的发展。然而,由于缺乏有效、安全的疼痛治疗方法,因此也需要靶向疗法来增加治疗选择,从而帮助减轻全球的痛苦负担。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neuropathic Pain: Mechanisms, Sex Differences, and Potential Therapies for a Global Problem.

The study of chronic pain continues to generate ever-increasing numbers of publications, but safe and efficacious treatments for chronic pain remain elusive. Recognition of sex-specific mechanisms underlying chronic pain has resulted in a surge of studies that include both sexes. A predominant focus has been on identifying sex differences, yet many newly identified cellular mechanisms and alterations in gene expression are conserved between the sexes. Here we review sex differences and similarities in cellular and molecular signals that drive the generation and resolution of neuropathic pain. The mix of differences and similarities reflects degeneracy in peripheral and central signaling processes by which neurons, immune cells, and glia codependently drive pain hypersensitivity. Recent findings identifying critical signaling nodes foreshadow the development of rationally designed, broadly applicable analgesic strategies. However, the paucity of effective, safe pain treatments compels targeted therapies as well to increase therapeutic options that help reduce the global burden of suffering.

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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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