Multiple Myeloma Relapsed with Skull Involvement in Plasmacytoma

Extra medullary plasmacytomas occurring as solitary (primary) tumours or secondary manifestations of multiple myeloma most often involve the upper airways and paranasal sinuses. The skull is one of the rarest sites of extra medullary plasmacytoma. Myelomatous deposits in dural reflections distant from the bony skull, i.e. tentorium and falx, are rarer, and probably result from dissection along layers of meninges. Osseous and pachymeningeal masses in the cranial vault or in the skull base may result in tumefaction, pain, headache, single or multiple cranial nerve palsies or seizure. A case of multiple myeloma relapsed with extra medullary plasmacytoma in the skull; forehead and ear involvement is reported.