“失联”——烧伤后感性的恢复:文献综述

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
S. Tsolakidis, Ziyad Alharbi, H. Rennekampff, Markus Schmidhammer, R. Schmidhammer, R. Rosenauer
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引用次数: 2

摘要

背景:全层烧伤(FTBI)不仅在社会生活和自尊方面造成重大负担,而且还通过多种方式降低敏感性对环境相互作用产生巨大影响。基于这些理由,恢复烧伤创面敏感性的可能方法和解决方案是必不可少的,不应忽视。方法:回顾实验、临床研究及相关文献,探讨烧伤后神经再生和感觉再整合的方法,以补充治疗理念。结果:在人类烧伤中,已经假设移植细胞,部分是多能干细胞,可能额外负责烧伤创面区域的神经再生。此外,在烧伤后短时间内进行烧伤痂切除,可以减少烧伤后毒性介质的释放,从而减少甚至避免长期的神经损伤。各种动物研究可以证明烧伤创面的感觉神经再生具有不同的性质。烧伤后瘢痕组织阻止或至少减缓神经再生,但可通过靶向介质减少。结论:在全层烧伤创面切除后,植皮区存在感觉丧失,从而导致生活质量下降。此外,各种介质可能减少或避免神经损伤,应在早期阶段考虑作为烧伤患者整体治疗方法的一部分。此外,支持多方面的物理治疗策略是必不可少的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
“Out of Touch”—Recovering Sensibility after Burn Injury: A Review of the Literature
Background: Full-thickness burn injuries (FTBI) not only lead to a significant burden in multiple ways, including social life and self-esteem, but have also a tremendous impact on environmental interaction by reducing sensibility in manifold ways. On these grounds, possible ways and solutions to recover sensibility in burn wounds are essentials and should not be overlooked. Methods: A review of experimental, clinical studies and the related literature was performed with the aim to highlight post-burn nerve regeneration and discover ways for sensory re-integration to complement the therapeutic concept. Results: In human burn injuries, it has been hypothesized that grafted cells, partly multipotent stem cells, could be additionally responsible for nerve regeneration in burn wound areas. In addition, burn eschar excision, performed within a short post-burn time frame, can reduce or even avoid long-term nerve damage by reducing post-burn toxic mediator release. Various animal studies could demonstrate sensory reinnervation of different qualities in burn wounds. Post-burn scar tissue prevents, or at least decelerates, nerve reinnervation, but could be reduced by targeted mediators. Conclusion: Sensory loss is present in skin grafted areas following full-thickness burn-wound excision, thereby leading to a reduction in quality of life. In addition, various mediators might reduce or avoid nerve damage and should be considered at an early stage as part of a holistic burn-patient therapeutic approach. In addition, supportive multifaceted physical therapy strategies are essential.
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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