没有证据表明健康人的特定器官代谢率有大量依赖性

IF 6.5 1区医学 Q1 NUTRITION & DIETETICS

American Journal of Clinical Nutrition Pub Date : 2008-10-01 DOI:10.1093/ajcn/88.4.1004

Wiebke Later , Anja Bosy-Westphal , Britta Hitze , Elke Kossel , C-C Glüer , Martin Heller , Manfred J Müller

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引用次数: 25

摘要

背景:在人类中，静息能量消耗(REE)可以使用恒定的特定器官代谢率从器官和组织质量中计算出来。然而，物种间数据表明，体重与器官代谢率之间存在异速生长关系，体重越小的哺乳动物的特定代谢率越高。目的:目的是比较REE预测与使用恒定或体重依赖的特定器官代谢率的准确性。设计:健康受试者(79名女性，75名男性)，年龄在18-78岁之间，在健康体重指数预期的脂肪量(FM)正常范围内，按体重分层。50例受试者分为三类:1组(<66.3 kg)， 52例为2组(≥66.3 ~≤77.2 kg)， 52例为3组(>77.2 kg)。磁共振成像评估4个内脏器官(脑、心、肝、肾)的体积。通过间接量热法(REEm)测量REE，并与先前公布的常量(REEc1)和体重依赖器官代谢率(REEc2)计算的REE进行比较。结果:REEm随重量的增加而显著增加(1:5536±529 kJ/d;瓷砖2:6389±672 kJ/d;瓷砖3:7467±745 kJ/d;P & lt;0.01)。REEm-REEc1的偏差在不同重量组间无差异(1组:66±382 kJ/d;瓷砖2:167±507 kJ/d;瓷砖3:86±480 kJ/d;NS)，与体重无关(r = - 0.05, NS)。与此相反，REEm-REEc2随着纤维重量的增加而增加(纤维1:−45±369 kJ/d;瓷砖2:150±503 kJ/d;瓷砖3:193±482 kJ/d;P & lt;0.05)，并与体重显著相关(r = 0.16, P <0.05)。结论:我们的数据不支持体重较大的人的特定器官代谢率低于体重较小的人。

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No evidence of mass dependency of specific organ metabolic rate in healthy humans1

Background: In humans, resting energy expenditure (REE) can be calculated from organ and tissue masses using constant specific organ metabolic rates. However, interspecies data suggest allometric relations between body mass and organ metabolic rate with higher specific metabolic rates in mammals with a smaller body mass.

Objective: The objective was to compare the accuracy of REE prediction with the use of either constant or body mass–dependent specific organ metabolic rates.

Design: Healthy subjects (79 women, 75 men) within the normal range of fat mass (FM) expected for a healthy body mass index and aged 18–78 y were stratified into tertiles of body mass. Fifty subjects were grouped as tertile 1 (<66.3 kg), 52 as tertile 2 (≥66.3 to ≤77.2 kg), and 52 as tertile 3 (>77.2 kg). Magnetic resonance imaging was used to assess the volume of 4 internal organs (brain, heart, liver, and kidneys). REE was measured by indirect calorimetry (REE_m) and compared with REE calculated from previously published constant (REE_c1) and body mass–dependent organ metabolic rates (REE_c2).

Results: REE_m increased significantly with weight tertile (tertile 1: 5536 ± 529 kJ/d; tertile 2: 6389 ± 672 kJ/d; tertile 3: 7467 ± 745 kJ/d; P < 0.01). The deviation REE_m–REE_c1 did not differ between weight tertiles (tertile 1: 66 ± 382 kJ/d; tertile 2: 167 ± 507 kJ/d; tertile 3: 86 ± 480 kJ/d; NS) and showed no relation with body mass (r = −0.05, NS). By contrast, REE_m–REE_c2 increased with increasing weight tertile (tertile 1: −45 ± 369 kJ/d; tertile 2: 150 ± 503 kJ/d; tertile 3: 193 ± 482 kJ/d; P < 0.05) and correlated significantly with body mass (r = 0.16, P < 0.05).

Conclusion: Our data do not support a lower specific organ metabolic rate in humans with a larger body mass than in those with a smaller body mass.

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来源期刊

American Journal of Clinical Nutrition 医学-营养学

CiteScore

12.40

自引率

4.20%

发文量

332

审稿时长

38 days

期刊介绍： American Journal of Clinical Nutrition is recognized as the most highly rated peer-reviewed, primary research journal in nutrition and dietetics.It focuses on publishing the latest research on various topics in nutrition, including but not limited to obesity, vitamins and minerals, nutrition and disease, and energy metabolism. Purpose: The purpose of AJCN is to: Publish original research studies relevant to human and clinical nutrition. Consider well-controlled clinical studies describing scientific mechanisms, efficacy, and safety of dietary interventions in the context of disease prevention or health benefits. Encourage public health and epidemiologic studies relevant to human nutrition. Promote innovative investigations of nutritional questions employing epigenetic, genomic, proteomic, and metabolomic approaches. Include solicited editorials, book reviews, solicited or unsolicited review articles, invited controversy position papers, and letters to the Editor related to prior AJCN articles. Peer Review Process: All submitted material with scientific content undergoes peer review by the Editors or their designees before acceptance for publication.