Verónica Rico-Caballero, Mariana Fernández, Juan C Hurtado, M Angeles Marcos, Celia Cardozo, Laia Albiach, Daiana Agüero, Juan Ambrosioni, Marta Bodro, Mariana Chumbita, Lorena De la Mora, Nicole Garcia-Pouton, Ana Gonzalez-Cordón, Gerard Dueñas, Marta Hernandez-Meneses, Alexy Inciarte, Montse Laguno, Lorna Leal, Irene Macaya, Miguel J Martínez, Genoveva Cuesta, Fernanda Meira, Laura Morata, Pedro Puerta-Alcalde, John Rojas, Berta Torres, Pedro Castro, Jose Muñoz, Josep Mensa, José Antonio Martínez, Gemma Sanjuan, Jordi Vila, Felipe García, Carolina Garcia-Vidal, Alex Soriano
{"title":"SARS-CoV-2 病毒载量和入院前症状持续时间对 COVID-19 住院患者死亡率的影响。","authors":"Verónica Rico-Caballero, Mariana Fernández, Juan C Hurtado, M Angeles Marcos, Celia Cardozo, Laia Albiach, Daiana Agüero, Juan Ambrosioni, Marta Bodro, Mariana Chumbita, Lorena De la Mora, Nicole Garcia-Pouton, Ana Gonzalez-Cordón, Gerard Dueñas, Marta Hernandez-Meneses, Alexy Inciarte, Montse Laguno, Lorna Leal, Irene Macaya, Miguel J Martínez, Genoveva Cuesta, Fernanda Meira, Laura Morata, Pedro Puerta-Alcalde, John Rojas, Berta Torres, Pedro Castro, Jose Muñoz, Josep Mensa, José Antonio Martínez, Gemma Sanjuan, Jordi Vila, Felipe García, Carolina Garcia-Vidal, Alex Soriano","doi":"10.1007/s15010-022-01833-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Assess the impact of viral load estimated by cycle threshold (Ct) of reverse transcription real time-polymerase chain reaction (rRT-PCR) and the days from symptoms onset on mortality in hospitalized patients with COVID19.</p><p><strong>Methods: </strong>Retrospective observational study of 782 patients with a positive rRT-PCR from a nasopharyngeal swab was performed within the first 24 h from admission. Demographic data, clinical manifestations and laboratory parameters were collected. Uni- and multivariate analyses were performed to identify factors associated with mortality at 60 days.</p><p><strong>Results: </strong>Ct was divided into three groups and the mortality rate decreased from 27.3 to 20.7% and 9.8% for Ct values of ≤ 20, 21-25 and > 25, respectively (P = 0.0001). The multivariate analysis identified as predictors of mortality, a Ct value < 20 (OR 3.13, CI 95% 1.38-7.10), between 21-25 (OR 2.47, CI 95% 1.32-4.64) with respect to a Ct value > 25. Days from symptoms onset is a variable associated with mortality as well (DSOA) ≤ 6 (OR 1.86, CI 95% 1.00-3.46), among other factors. Patients requiring hospital admission within 6 DSOA with a Ct value ≤ 25 had the highest mortality rate (28%).</p><p><strong>Conclusions: </strong>The inclusion of Ct values and DSOA in the characterization of study populations could be a useful tool to evaluate the efficacy of antivirals.</p>","PeriodicalId":52452,"journal":{"name":"European Review of Latin American and Caribbean Studies","volume":"1 1","pages":"1321-1328"},"PeriodicalIF":0.0000,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105593/pdf/","citationCount":"0","resultStr":"{\"title\":\"Impact of SARS-CoV-2 viral load and duration of symptoms before hospital admission on the mortality of hospitalized COVID-19 patients.\",\"authors\":\"Verónica Rico-Caballero, Mariana Fernández, Juan C Hurtado, M Angeles Marcos, Celia Cardozo, Laia Albiach, Daiana Agüero, Juan Ambrosioni, Marta Bodro, Mariana Chumbita, Lorena De la Mora, Nicole Garcia-Pouton, Ana Gonzalez-Cordón, Gerard Dueñas, Marta Hernandez-Meneses, Alexy Inciarte, Montse Laguno, Lorna Leal, Irene Macaya, Miguel J Martínez, Genoveva Cuesta, Fernanda Meira, Laura Morata, Pedro Puerta-Alcalde, John Rojas, Berta Torres, Pedro Castro, Jose Muñoz, Josep Mensa, José Antonio Martínez, Gemma Sanjuan, Jordi Vila, Felipe García, Carolina Garcia-Vidal, Alex Soriano\",\"doi\":\"10.1007/s15010-022-01833-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Assess the impact of viral load estimated by cycle threshold (Ct) of reverse transcription real time-polymerase chain reaction (rRT-PCR) and the days from symptoms onset on mortality in hospitalized patients with COVID19.</p><p><strong>Methods: </strong>Retrospective observational study of 782 patients with a positive rRT-PCR from a nasopharyngeal swab was performed within the first 24 h from admission. Demographic data, clinical manifestations and laboratory parameters were collected. Uni- and multivariate analyses were performed to identify factors associated with mortality at 60 days.</p><p><strong>Results: </strong>Ct was divided into three groups and the mortality rate decreased from 27.3 to 20.7% and 9.8% for Ct values of ≤ 20, 21-25 and > 25, respectively (P = 0.0001). The multivariate analysis identified as predictors of mortality, a Ct value < 20 (OR 3.13, CI 95% 1.38-7.10), between 21-25 (OR 2.47, CI 95% 1.32-4.64) with respect to a Ct value > 25. Days from symptoms onset is a variable associated with mortality as well (DSOA) ≤ 6 (OR 1.86, CI 95% 1.00-3.46), among other factors. Patients requiring hospital admission within 6 DSOA with a Ct value ≤ 25 had the highest mortality rate (28%).</p><p><strong>Conclusions: </strong>The inclusion of Ct values and DSOA in the characterization of study populations could be a useful tool to evaluate the efficacy of antivirals.</p>\",\"PeriodicalId\":52452,\"journal\":{\"name\":\"European Review of Latin American and Caribbean Studies\",\"volume\":\"1 1\",\"pages\":\"1321-1328\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105593/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Review of Latin American and Caribbean Studies\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s15010-022-01833-8\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/5/13 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"Arts and Humanities\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Review of Latin American and Caribbean Studies","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s15010-022-01833-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/5/13 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"Arts and Humanities","Score":null,"Total":0}
Impact of SARS-CoV-2 viral load and duration of symptoms before hospital admission on the mortality of hospitalized COVID-19 patients.
Purpose: Assess the impact of viral load estimated by cycle threshold (Ct) of reverse transcription real time-polymerase chain reaction (rRT-PCR) and the days from symptoms onset on mortality in hospitalized patients with COVID19.
Methods: Retrospective observational study of 782 patients with a positive rRT-PCR from a nasopharyngeal swab was performed within the first 24 h from admission. Demographic data, clinical manifestations and laboratory parameters were collected. Uni- and multivariate analyses were performed to identify factors associated with mortality at 60 days.
Results: Ct was divided into three groups and the mortality rate decreased from 27.3 to 20.7% and 9.8% for Ct values of ≤ 20, 21-25 and > 25, respectively (P = 0.0001). The multivariate analysis identified as predictors of mortality, a Ct value < 20 (OR 3.13, CI 95% 1.38-7.10), between 21-25 (OR 2.47, CI 95% 1.32-4.64) with respect to a Ct value > 25. Days from symptoms onset is a variable associated with mortality as well (DSOA) ≤ 6 (OR 1.86, CI 95% 1.00-3.46), among other factors. Patients requiring hospital admission within 6 DSOA with a Ct value ≤ 25 had the highest mortality rate (28%).
Conclusions: The inclusion of Ct values and DSOA in the characterization of study populations could be a useful tool to evaluate the efficacy of antivirals.
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