新型氧化锌灰黄霉素纳米颗粒的合成及其对毛癣菌和疣状毛癣菌的抑菌活性的初步研究。

Q3 Medicine
Ali Abdul Hussein S Al-Janabi, Abas Matrood Bashi
{"title":"新型氧化锌灰黄霉素纳米颗粒的合成及其对毛癣菌和疣状毛癣菌的抑菌活性的初步研究。","authors":"Ali Abdul Hussein S Al-Janabi,&nbsp;Abas Matrood Bashi","doi":"10.18502/cmm.8.2.10331","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and purpose: </strong>Dermatophytoses is an important type of skin disease caused by dermatophytes. The long-term treatment of this disease with standard antifungal agents may be improved through the application of nanotechnology. This study aimed to prepare nanoparticles of griseofulvin with zinc oxide and assess its antifungal action.</p><p><strong>Materials and methods: </strong>Nanoparticles of griseofulvin with zinc oxide (GF-ZnO NPs) were prepared. Physical characteristics of new preparation and antidermatophytic action against two species of dermatophytes (<i>Trichophyton mentagrophytes</i> and <i>Trichophyton verrucosum</i>) were investigated. Testing of two species was considered a primary test for antifungals of griseofulvin nanoparticles.</p><p><strong>Results: </strong>Physical examination indicated that GF-ZnO NPs had typical nanoparticle characteristics. A new formulation showed effective inhibitory action against two fungal species with higher efficiency than that of griseofulvin. <i>T. mentagrophytes</i> required a higher MIC value (0.0625 µg/mL) of GF-ZnO NPs than that required by <i>T. verrucosum</i> (0.031 µg/mL).</p><p><strong>Conclusion: </strong>GF-ZnO NPs revealed an effective action against dermatophytes compared to griseofulvin alone. Nanoparticles containing griseofulvin may be used in the development of a novel drug for the treatment of dermatophytosis.</p>","PeriodicalId":10863,"journal":{"name":"Current Medical Mycology","volume":"8 2","pages":"40-44"},"PeriodicalIF":0.0000,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825792/pdf/","citationCount":"0","resultStr":"{\"title\":\"Synthesis and antifungal activity of novel griseofulvin nanoparticles with zinc oxide against dermatophytic fungi: <i>Trichophyton mentagrophytes</i> and <i>Trichophyton verrucosum</i>: A primary study.\",\"authors\":\"Ali Abdul Hussein S Al-Janabi,&nbsp;Abas Matrood Bashi\",\"doi\":\"10.18502/cmm.8.2.10331\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and purpose: </strong>Dermatophytoses is an important type of skin disease caused by dermatophytes. The long-term treatment of this disease with standard antifungal agents may be improved through the application of nanotechnology. This study aimed to prepare nanoparticles of griseofulvin with zinc oxide and assess its antifungal action.</p><p><strong>Materials and methods: </strong>Nanoparticles of griseofulvin with zinc oxide (GF-ZnO NPs) were prepared. Physical characteristics of new preparation and antidermatophytic action against two species of dermatophytes (<i>Trichophyton mentagrophytes</i> and <i>Trichophyton verrucosum</i>) were investigated. Testing of two species was considered a primary test for antifungals of griseofulvin nanoparticles.</p><p><strong>Results: </strong>Physical examination indicated that GF-ZnO NPs had typical nanoparticle characteristics. A new formulation showed effective inhibitory action against two fungal species with higher efficiency than that of griseofulvin. <i>T. mentagrophytes</i> required a higher MIC value (0.0625 µg/mL) of GF-ZnO NPs than that required by <i>T. verrucosum</i> (0.031 µg/mL).</p><p><strong>Conclusion: </strong>GF-ZnO NPs revealed an effective action against dermatophytes compared to griseofulvin alone. Nanoparticles containing griseofulvin may be used in the development of a novel drug for the treatment of dermatophytosis.</p>\",\"PeriodicalId\":10863,\"journal\":{\"name\":\"Current Medical Mycology\",\"volume\":\"8 2\",\"pages\":\"40-44\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825792/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Medical Mycology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18502/cmm.8.2.10331\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Medical Mycology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18502/cmm.8.2.10331","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

摘要

背景与目的:皮癣病是由皮癣菌引起的一种重要的皮肤病。通过纳米技术的应用,可以改善使用标准抗真菌药物对这种疾病的长期治疗。以氧化锌为原料制备灰黄霉素纳米颗粒,并对其抑菌作用进行了研究。材料与方法:制备了氧化锌灰黄霉素纳米颗粒(GF-ZnO NPs)。研究了新制剂的物理特性及其对两种皮癣菌(毛癣菌和疣毛癣菌)的抑菌作用。灰黄霉素纳米颗粒抗真菌的主要测试方法是对两个物种进行测试。结果:体格检查表明GF-ZnO NPs具有典型的纳米颗粒特征。新配方对两种真菌均有较好的抑菌效果,抑菌效果优于灰黄霉素。褐藓对GF-ZnO NPs的MIC值(0.0625µg/mL)高于疣草对GF-ZnO NPs的MIC值(0.031µg/mL)。结论:GF-ZnO NPs具有较强的抗皮肤真菌活性。含有灰黄霉素的纳米颗粒可用于开发治疗皮肤真菌病的新药。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Synthesis and antifungal activity of novel griseofulvin nanoparticles with zinc oxide against dermatophytic fungi: <i>Trichophyton mentagrophytes</i> and <i>Trichophyton verrucosum</i>: A primary study.

Synthesis and antifungal activity of novel griseofulvin nanoparticles with zinc oxide against dermatophytic fungi: <i>Trichophyton mentagrophytes</i> and <i>Trichophyton verrucosum</i>: A primary study.

Synthesis and antifungal activity of novel griseofulvin nanoparticles with zinc oxide against dermatophytic fungi: Trichophyton mentagrophytes and Trichophyton verrucosum: A primary study.

Background and purpose: Dermatophytoses is an important type of skin disease caused by dermatophytes. The long-term treatment of this disease with standard antifungal agents may be improved through the application of nanotechnology. This study aimed to prepare nanoparticles of griseofulvin with zinc oxide and assess its antifungal action.

Materials and methods: Nanoparticles of griseofulvin with zinc oxide (GF-ZnO NPs) were prepared. Physical characteristics of new preparation and antidermatophytic action against two species of dermatophytes (Trichophyton mentagrophytes and Trichophyton verrucosum) were investigated. Testing of two species was considered a primary test for antifungals of griseofulvin nanoparticles.

Results: Physical examination indicated that GF-ZnO NPs had typical nanoparticle characteristics. A new formulation showed effective inhibitory action against two fungal species with higher efficiency than that of griseofulvin. T. mentagrophytes required a higher MIC value (0.0625 µg/mL) of GF-ZnO NPs than that required by T. verrucosum (0.031 µg/mL).

Conclusion: GF-ZnO NPs revealed an effective action against dermatophytes compared to griseofulvin alone. Nanoparticles containing griseofulvin may be used in the development of a novel drug for the treatment of dermatophytosis.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Current Medical Mycology
Current Medical Mycology Medicine-Infectious Diseases
CiteScore
2.10
自引率
0.00%
发文量
16
审稿时长
4 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信